High heparin released platelet factor 4 in uncomplicated type 1 diabetes mellitus

M. Cortellaro, E. Cofrancesco, A. Vicari, C. Boschetti, A. Della Volpe, G. Moreo, G. Pozza, E. E. Polli

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The role of platelet activation in diabetic microangio-pathy is still controversial. We evaluated the degree of platelet activation in relation to vessel wall damage in three selected, well matched groups of subjects (10 healthy controls; 20 insulin dependent diabetic patients, 10 without microangiopathy and 10 with microangiopathy). We measured βTG and PF4 plasma levels before and 5, 15 and 90 min after a heparin bolus i.v. (5000 U). βTG basal levels were increased only in diabetic patients with microangiopathy. Diabetic patients without microangiopathy showed significantly higher levels of heparin released-PF4 (HR-PF4) in comparison with healthy controls. High levels of HR-PF4 seen to be an early marker of in vivo increased platelet activation in uncomplicated diabetes mellitus.

Original languageEnglish
Pages (from-to)571-576
Number of pages6
JournalThrombosis Research
Volume58
Issue number6
DOIs
Publication statusPublished - Jun 15 1990

Fingerprint

Platelet Factor 4
Platelet Activation
Type 1 Diabetes Mellitus
Heparin
Diabetes Mellitus
Healthy Volunteers
Research Design
Insulin

Keywords

  • diabetes mellitus
  • endothelial cell function
  • heparin-released PF4
  • platelet activation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Cite this

Cortellaro, M., Cofrancesco, E., Vicari, A., Boschetti, C., Della Volpe, A., Moreo, G., ... Polli, E. E. (1990). High heparin released platelet factor 4 in uncomplicated type 1 diabetes mellitus. Thrombosis Research, 58(6), 571-576. https://doi.org/10.1016/0049-3848(90)90303-T

High heparin released platelet factor 4 in uncomplicated type 1 diabetes mellitus. / Cortellaro, M.; Cofrancesco, E.; Vicari, A.; Boschetti, C.; Della Volpe, A.; Moreo, G.; Pozza, G.; Polli, E. E.

In: Thrombosis Research, Vol. 58, No. 6, 15.06.1990, p. 571-576.

Research output: Contribution to journalArticle

Cortellaro, M, Cofrancesco, E, Vicari, A, Boschetti, C, Della Volpe, A, Moreo, G, Pozza, G & Polli, EE 1990, 'High heparin released platelet factor 4 in uncomplicated type 1 diabetes mellitus', Thrombosis Research, vol. 58, no. 6, pp. 571-576. https://doi.org/10.1016/0049-3848(90)90303-T
Cortellaro, M. ; Cofrancesco, E. ; Vicari, A. ; Boschetti, C. ; Della Volpe, A. ; Moreo, G. ; Pozza, G. ; Polli, E. E. / High heparin released platelet factor 4 in uncomplicated type 1 diabetes mellitus. In: Thrombosis Research. 1990 ; Vol. 58, No. 6. pp. 571-576.
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