High heparin released platelet factor 4 in uncomplicated type 1 diabetes mellitus

M. Cortellaro, E. Cofrancesco, A. Vicari, C. Boschetti, A. Della Volpe, G. Moreo, G. Pozza, E. E. Polli

Research output: Contribution to journalArticlepeer-review


The role of platelet activation in diabetic microangio-pathy is still controversial. We evaluated the degree of platelet activation in relation to vessel wall damage in three selected, well matched groups of subjects (10 healthy controls; 20 insulin dependent diabetic patients, 10 without microangiopathy and 10 with microangiopathy). We measured βTG and PF4 plasma levels before and 5, 15 and 90 min after a heparin bolus i.v. (5000 U). βTG basal levels were increased only in diabetic patients with microangiopathy. Diabetic patients without microangiopathy showed significantly higher levels of heparin released-PF4 (HR-PF4) in comparison with healthy controls. High levels of HR-PF4 seen to be an early marker of in vivo increased platelet activation in uncomplicated diabetes mellitus.

Original languageEnglish
Pages (from-to)571-576
Number of pages6
JournalThrombosis Research
Issue number6
Publication statusPublished - Jun 15 1990


  • diabetes mellitus
  • endothelial cell function
  • heparin-released PF4
  • platelet activation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology


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