TY - JOUR
T1 - High level expression of the HMGI (Y) gene during embryonic development
AU - Chiappetta, Gennaro
AU - Avantaggiato, Virginia
AU - Visconti, Roberta
AU - Fedele, Monica
AU - Battista, Sabrina
AU - Trapasso, Francesco
AU - Merciai, Bianca Maria
AU - Fidanza, Vincenzo
AU - Giancotti, Vincenzo
AU - Santoro, Massimo
AU - Simeone, Antonio
AU - Fusco, Alfredo
PY - 1996
Y1 - 1996
N2 - The HMGI protein family includes three proteins, named HMG-I, HMG-Y and HMGI-C. The first two proteins are coded for by the same gene, HMGI (Y), through an alternative splicing mechanism. Their expression is elevated in neoplastic tissues and cells and this over-expression has a causal role in the process of cellular neoplastic transformation. We demonstrate that the HMGI(Y) gene is expressed at very low levels in normal adult tissues, whereas in embryonic tissues it is expressed at high levels comparable to those detected in neoplastic tissues. Specifically, a very high expression of the HMGI (Y) gene was detected in all embryonic tissues at 8.5 dpc. Then in the following days, even though the gene is expressed essentially in all tissues, an abundant gene expression was restricted to some tissues. These results indicate an important role of the HMGI (Y) gene in development.
AB - The HMGI protein family includes three proteins, named HMG-I, HMG-Y and HMGI-C. The first two proteins are coded for by the same gene, HMGI (Y), through an alternative splicing mechanism. Their expression is elevated in neoplastic tissues and cells and this over-expression has a causal role in the process of cellular neoplastic transformation. We demonstrate that the HMGI(Y) gene is expressed at very low levels in normal adult tissues, whereas in embryonic tissues it is expressed at high levels comparable to those detected in neoplastic tissues. Specifically, a very high expression of the HMGI (Y) gene was detected in all embryonic tissues at 8.5 dpc. Then in the following days, even though the gene is expressed essentially in all tissues, an abundant gene expression was restricted to some tissues. These results indicate an important role of the HMGI (Y) gene in development.
KW - Development
KW - Embryo
KW - HMGI proteins
KW - in situ hybridization
UR - http://www.scopus.com/inward/record.url?scp=8044225313&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=8044225313&partnerID=8YFLogxK
M3 - Article
C2 - 8957086
AN - SCOPUS:8044225313
VL - 13
SP - 2439
EP - 2446
JO - Oncogene
JF - Oncogene
SN - 0950-9232
IS - 11
ER -