High level expression of the HMGI (Y) gene during embryonic development

Gennaro Chiappetta; Virginia Avantaggiato; Roberta Visconti; Monica Fedele; Sabrina Battista; Francesco Trapasso; Bianca Maria Merciai; Vincenzo Fidanza; Vincenzo Giancotti; Massimo Santoro; Antonio Simeone; Alfredo Fusco

High level expression of the HMGI (Y) gene during embryonic development

Gennaro Chiappetta, Virginia Avantaggiato, Roberta Visconti, Monica Fedele, Sabrina Battista, Francesco Trapasso, Bianca Maria Merciai, Vincenzo Fidanza, Vincenzo Giancotti, Massimo Santoro, Antonio Simeone, Alfredo Fusco

Research output: Contribution to journal › Article

Abstract

The HMGI protein family includes three proteins, named HMG-I, HMG-Y and HMGI-C. The first two proteins are coded for by the same gene, HMGI (Y), through an alternative splicing mechanism. Their expression is elevated in neoplastic tissues and cells and this over-expression has a causal role in the process of cellular neoplastic transformation. We demonstrate that the HMGI(Y) gene is expressed at very low levels in normal adult tissues, whereas in embryonic tissues it is expressed at high levels comparable to those detected in neoplastic tissues. Specifically, a very high expression of the HMGI (Y) gene was detected in all embryonic tissues at 8.5 dpc. Then in the following days, even though the gene is expressed essentially in all tissues, an abundant gene expression was restricted to some tissues. These results indicate an important role of the HMGI (Y) gene in development.

Original language	English
Pages (from-to)	2439-2446
Number of pages	8
Journal	Oncogene
Volume	13
Issue number	11
Publication status	Published - 1996

Keywords

Development
Embryo
HMGI proteins
in situ hybridization

ASJC Scopus subject areas

Molecular Biology
Cancer Research
Genetics

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Chiappetta, G., Avantaggiato, V., Visconti, R., Fedele, M., Battista, S., Trapasso, F., Merciai, B. M., Fidanza, V., Giancotti, V., Santoro, M., Simeone, A., & Fusco, A. (1996). High level expression of the HMGI (Y) gene during embryonic development. Oncogene, 13(11), 2439-2446.

High level expression of the HMGI (Y) gene during embryonic development. / Chiappetta, Gennaro; Avantaggiato, Virginia; Visconti, Roberta; Fedele, Monica; Battista, Sabrina; Trapasso, Francesco; Merciai, Bianca Maria; Fidanza, Vincenzo; Giancotti, Vincenzo; Santoro, Massimo; Simeone, Antonio; Fusco, Alfredo.

In: Oncogene, Vol. 13, No. 11, 1996, p. 2439-2446.

Research output: Contribution to journal › Article

Chiappetta, Gennaro ; Avantaggiato, Virginia ; Visconti, Roberta ; Fedele, Monica ; Battista, Sabrina ; Trapasso, Francesco ; Merciai, Bianca Maria ; Fidanza, Vincenzo ; Giancotti, Vincenzo ; Santoro, Massimo ; Simeone, Antonio ; Fusco, Alfredo. / High level expression of the HMGI (Y) gene during embryonic development. In: Oncogene. 1996 ; Vol. 13, No. 11. pp. 2439-2446.

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abstract = "The HMGI protein family includes three proteins, named HMG-I, HMG-Y and HMGI-C. The first two proteins are coded for by the same gene, HMGI (Y), through an alternative splicing mechanism. Their expression is elevated in neoplastic tissues and cells and this over-expression has a causal role in the process of cellular neoplastic transformation. We demonstrate that the HMGI(Y) gene is expressed at very low levels in normal adult tissues, whereas in embryonic tissues it is expressed at high levels comparable to those detected in neoplastic tissues. Specifically, a very high expression of the HMGI (Y) gene was detected in all embryonic tissues at 8.5 dpc. Then in the following days, even though the gene is expressed essentially in all tissues, an abundant gene expression was restricted to some tissues. These results indicate an important role of the HMGI (Y) gene in development.",

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AU - Trapasso, Francesco

AU - Merciai, Bianca Maria

AU - Fidanza, Vincenzo

AU - Giancotti, Vincenzo

AU - Santoro, Massimo

AU - Simeone, Antonio

AU - Fusco, Alfredo

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