High level expression of the HMGI (Y) gene during embryonic development

Gennaro Chiappetta, Virginia Avantaggiato, Roberta Visconti, Monica Fedele, Sabrina Battista, Francesco Trapasso, Bianca Maria Merciai, Vincenzo Fidanza, Vincenzo Giancotti, Massimo Santoro, Antonio Simeone, Alfredo Fusco

Research output: Contribution to journalArticle

Abstract

The HMGI protein family includes three proteins, named HMG-I, HMG-Y and HMGI-C. The first two proteins are coded for by the same gene, HMGI (Y), through an alternative splicing mechanism. Their expression is elevated in neoplastic tissues and cells and this over-expression has a causal role in the process of cellular neoplastic transformation. We demonstrate that the HMGI(Y) gene is expressed at very low levels in normal adult tissues, whereas in embryonic tissues it is expressed at high levels comparable to those detected in neoplastic tissues. Specifically, a very high expression of the HMGI (Y) gene was detected in all embryonic tissues at 8.5 dpc. Then in the following days, even though the gene is expressed essentially in all tissues, an abundant gene expression was restricted to some tissues. These results indicate an important role of the HMGI (Y) gene in development.

Original languageEnglish
Pages (from-to)2439-2446
Number of pages8
JournalOncogene
Volume13
Issue number11
Publication statusPublished - 1996

Keywords

  • Development
  • Embryo
  • HMGI proteins
  • in situ hybridization

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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  • Cite this

    Chiappetta, G., Avantaggiato, V., Visconti, R., Fedele, M., Battista, S., Trapasso, F., Merciai, B. M., Fidanza, V., Giancotti, V., Santoro, M., Simeone, A., & Fusco, A. (1996). High level expression of the HMGI (Y) gene during embryonic development. Oncogene, 13(11), 2439-2446.