Abstract
Antiphospholipid antibodies (APA) are a family of autoimmune and alloimmune immunoglobulins recognizing protein-phospholipid complexes in in vitro laboratory test systems. These antibodies have been associated with several conditions (malignancies, autoimmune diseases, infections, use of drugs); moreover, a syndrome capable of inducing thromboembolic disease has recently been associated with the presence of these antibodies. The aim of this prospective study was to investigate the levels of APA in subjects affected by haematological malignancies undergoing allogeneic haematopoietic stem cell transplantation (ASCT). Between March 1996 and December 1997, 32 patients undergoing ASCT were studied prospectively until day +180 from transplant. The mean values of IgG and IgM anticardiolipin antibodies (ACA) increased in recipients of stem cells from an unrelated donor, and a statistically significant difference in ACA IgG mean value between unrelated and related transplanted patients was demonstrated between days +95 and +180. All of the subjects who received stem cells from an unrelated donor had APA levels higher than the mean normal value +3 SD vs. 35% of those receiving stem cells from a related donor (P
| Original language | English |
|---|---|
| Pages (from-to) | 126-131 |
| Number of pages | 6 |
| Journal | British Journal of Haematology |
| Volume | 108 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2000 |
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Keywords
- Antiphospholipid antibodies
- B lymphocytes
- Cytomegalovirus infection
- Umbilical cord blood transplantation
- Unrelated allogeneic stem cell transplantation
ASJC Scopus subject areas
- Hematology
Cite this
High levels of antiphospholipid antibodies are associated with cytomegalovirus infection in unrelated bone marrow and cord blood allogeneic stem cell transplantation. / Mengarelli, Andrea; Minotti, Clara; Palumbo, Giovanna; Arcieri, Paolo; Gentile, Giuseppe; Iori, Anna Paola; Arcese, William; Mandelli, Franco; Avvisati, Giuseppe.
In: British Journal of Haematology, Vol. 108, No. 1, 2000, p. 126-131.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High levels of antiphospholipid antibodies are associated with cytomegalovirus infection in unrelated bone marrow and cord blood allogeneic stem cell transplantation
AU - Mengarelli, Andrea
AU - Minotti, Clara
AU - Palumbo, Giovanna
AU - Arcieri, Paolo
AU - Gentile, Giuseppe
AU - Iori, Anna Paola
AU - Arcese, William
AU - Mandelli, Franco
AU - Avvisati, Giuseppe
PY - 2000
Y1 - 2000
N2 - Antiphospholipid antibodies (APA) are a family of autoimmune and alloimmune immunoglobulins recognizing protein-phospholipid complexes in in vitro laboratory test systems. These antibodies have been associated with several conditions (malignancies, autoimmune diseases, infections, use of drugs); moreover, a syndrome capable of inducing thromboembolic disease has recently been associated with the presence of these antibodies. The aim of this prospective study was to investigate the levels of APA in subjects affected by haematological malignancies undergoing allogeneic haematopoietic stem cell transplantation (ASCT). Between March 1996 and December 1997, 32 patients undergoing ASCT were studied prospectively until day +180 from transplant. The mean values of IgG and IgM anticardiolipin antibodies (ACA) increased in recipients of stem cells from an unrelated donor, and a statistically significant difference in ACA IgG mean value between unrelated and related transplanted patients was demonstrated between days +95 and +180. All of the subjects who received stem cells from an unrelated donor had APA levels higher than the mean normal value +3 SD vs. 35% of those receiving stem cells from a related donor (P
AB - Antiphospholipid antibodies (APA) are a family of autoimmune and alloimmune immunoglobulins recognizing protein-phospholipid complexes in in vitro laboratory test systems. These antibodies have been associated with several conditions (malignancies, autoimmune diseases, infections, use of drugs); moreover, a syndrome capable of inducing thromboembolic disease has recently been associated with the presence of these antibodies. The aim of this prospective study was to investigate the levels of APA in subjects affected by haematological malignancies undergoing allogeneic haematopoietic stem cell transplantation (ASCT). Between March 1996 and December 1997, 32 patients undergoing ASCT were studied prospectively until day +180 from transplant. The mean values of IgG and IgM anticardiolipin antibodies (ACA) increased in recipients of stem cells from an unrelated donor, and a statistically significant difference in ACA IgG mean value between unrelated and related transplanted patients was demonstrated between days +95 and +180. All of the subjects who received stem cells from an unrelated donor had APA levels higher than the mean normal value +3 SD vs. 35% of those receiving stem cells from a related donor (P
KW - Antiphospholipid antibodies
KW - B lymphocytes
KW - Cytomegalovirus infection
KW - Umbilical cord blood transplantation
KW - Unrelated allogeneic stem cell transplantation
UR - http://www.scopus.com/inward/record.url?scp=0033982435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033982435&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2141.2000.01812.x
DO - 10.1046/j.1365-2141.2000.01812.x
M3 - Article
C2 - 10651735
AN - SCOPUS:0033982435
VL - 108
SP - 126
EP - 131
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 1
ER -