High levels of antiphospholipid antibodies are associated with cytomegalovirus infection in unrelated bone marrow and cord blood allogeneic stem cell transplantation

Andrea Mengarelli, Clara Minotti, Giovanna Palumbo, Paolo Arcieri, Giuseppe Gentile, Anna Paola Iori, William Arcese, Franco Mandelli, Giuseppe Avvisati

Research output: Contribution to journalArticle

Abstract

Antiphospholipid antibodies (APA) are a family of autoimmune and alloimmune immunoglobulins recognizing protein-phospholipid complexes in in vitro laboratory test systems. These antibodies have been associated with several conditions (malignancies, autoimmune diseases, infections, use of drugs); moreover, a syndrome capable of inducing thromboembolic disease has recently been associated with the presence of these antibodies. The aim of this prospective study was to investigate the levels of APA in subjects affected by haematological malignancies undergoing allogeneic haematopoietic stem cell transplantation (ASCT). Between March 1996 and December 1997, 32 patients undergoing ASCT were studied prospectively until day +180 from transplant. The mean values of IgG and IgM anticardiolipin antibodies (ACA) increased in recipients of stem cells from an unrelated donor, and a statistically significant difference in ACA IgG mean value between unrelated and related transplanted patients was demonstrated between days +95 and +180. All of the subjects who received stem cells from an unrelated donor had APA levels higher than the mean normal value +3 SD vs. 35% of those receiving stem cells from a related donor (P

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalBritish Journal of Haematology
Volume108
Issue number1
DOIs
Publication statusPublished - 2000

Keywords

  • Antiphospholipid antibodies
  • B lymphocytes
  • Cytomegalovirus infection
  • Umbilical cord blood transplantation
  • Unrelated allogeneic stem cell transplantation

ASJC Scopus subject areas

  • Hematology

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