High levels of antiphospholipid antibodies are associated with cytomegalovirus infection in unrelated bone marrow and cord blood allogeneic stem cell transplantation

Andrea Mengarelli, Clara Minotti, Giovanna Palumbo, Paolo Arcieri, Giuseppe Gentile, Anna Paola Iori, William Arcese, Franco Mandelli, Giuseppe Avvisati

Research output: Contribution to journalArticle

Abstract

Antiphospholipid antibodies (APA) are a family of autoimmune and alloimmune immunoglobulins recognizing protein-phospholipid complexes in in vitro laboratory test systems. These antibodies have been associated with several conditions (malignancies, autoimmune diseases, infections, use of drugs); moreover, a syndrome capable of inducing thromboembolic disease has recently been associated with the presence of these antibodies. The aim of this prospective study was to investigate the levels of APA in subjects affected by haematological malignancies undergoing allogeneic haematopoietic stem cell transplantation (ASCT). Between March 1996 and December 1997, 32 patients undergoing ASCT were studied prospectively until day +180 from transplant. The mean values of IgG and IgM anticardiolipin antibodies (ACA) increased in recipients of stem cells from an unrelated donor, and a statistically significant difference in ACA IgG mean value between unrelated and related transplanted patients was demonstrated between days +95 and +180. All of the subjects who received stem cells from an unrelated donor had APA levels higher than the mean normal value +3 SD vs. 35% of those receiving stem cells from a related donor (P

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalBritish Journal of Haematology
Volume108
Issue number1
DOIs
Publication statusPublished - 2000

Fingerprint

Cord Blood Stem Cell Transplantation
Antiphospholipid Antibodies
Cytomegalovirus Infections
Anticardiolipin Antibodies
Unrelated Donors
Stem Cells
Bone Marrow
Hematopoietic Stem Cell Transplantation
Immunoglobulin G
Antibodies
Hematologic Neoplasms
Autoimmune Diseases
Immunoglobulin M
Immunoglobulins
Phospholipids
Reference Values
Tissue Donors
Prospective Studies
Transplants
Infection

Keywords

  • Antiphospholipid antibodies
  • B lymphocytes
  • Cytomegalovirus infection
  • Umbilical cord blood transplantation
  • Unrelated allogeneic stem cell transplantation

ASJC Scopus subject areas

  • Hematology

Cite this

High levels of antiphospholipid antibodies are associated with cytomegalovirus infection in unrelated bone marrow and cord blood allogeneic stem cell transplantation. / Mengarelli, Andrea; Minotti, Clara; Palumbo, Giovanna; Arcieri, Paolo; Gentile, Giuseppe; Iori, Anna Paola; Arcese, William; Mandelli, Franco; Avvisati, Giuseppe.

In: British Journal of Haematology, Vol. 108, No. 1, 2000, p. 126-131.

Research output: Contribution to journalArticle

Mengarelli, Andrea ; Minotti, Clara ; Palumbo, Giovanna ; Arcieri, Paolo ; Gentile, Giuseppe ; Iori, Anna Paola ; Arcese, William ; Mandelli, Franco ; Avvisati, Giuseppe. / High levels of antiphospholipid antibodies are associated with cytomegalovirus infection in unrelated bone marrow and cord blood allogeneic stem cell transplantation. In: British Journal of Haematology. 2000 ; Vol. 108, No. 1. pp. 126-131.
@article{17089e4a9a6d45da88f3119d6fb43f68,
title = "High levels of antiphospholipid antibodies are associated with cytomegalovirus infection in unrelated bone marrow and cord blood allogeneic stem cell transplantation",
abstract = "Antiphospholipid antibodies (APA) are a family of autoimmune and alloimmune immunoglobulins recognizing protein-phospholipid complexes in in vitro laboratory test systems. These antibodies have been associated with several conditions (malignancies, autoimmune diseases, infections, use of drugs); moreover, a syndrome capable of inducing thromboembolic disease has recently been associated with the presence of these antibodies. The aim of this prospective study was to investigate the levels of APA in subjects affected by haematological malignancies undergoing allogeneic haematopoietic stem cell transplantation (ASCT). Between March 1996 and December 1997, 32 patients undergoing ASCT were studied prospectively until day +180 from transplant. The mean values of IgG and IgM anticardiolipin antibodies (ACA) increased in recipients of stem cells from an unrelated donor, and a statistically significant difference in ACA IgG mean value between unrelated and related transplanted patients was demonstrated between days +95 and +180. All of the subjects who received stem cells from an unrelated donor had APA levels higher than the mean normal value +3 SD vs. 35{\%} of those receiving stem cells from a related donor (P",
keywords = "Antiphospholipid antibodies, B lymphocytes, Cytomegalovirus infection, Umbilical cord blood transplantation, Unrelated allogeneic stem cell transplantation",
author = "Andrea Mengarelli and Clara Minotti and Giovanna Palumbo and Paolo Arcieri and Giuseppe Gentile and Iori, {Anna Paola} and William Arcese and Franco Mandelli and Giuseppe Avvisati",
year = "2000",
doi = "10.1046/j.1365-2141.2000.01812.x",
language = "English",
volume = "108",
pages = "126--131",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "1",

}

TY - JOUR

T1 - High levels of antiphospholipid antibodies are associated with cytomegalovirus infection in unrelated bone marrow and cord blood allogeneic stem cell transplantation

AU - Mengarelli, Andrea

AU - Minotti, Clara

AU - Palumbo, Giovanna

AU - Arcieri, Paolo

AU - Gentile, Giuseppe

AU - Iori, Anna Paola

AU - Arcese, William

AU - Mandelli, Franco

AU - Avvisati, Giuseppe

PY - 2000

Y1 - 2000

N2 - Antiphospholipid antibodies (APA) are a family of autoimmune and alloimmune immunoglobulins recognizing protein-phospholipid complexes in in vitro laboratory test systems. These antibodies have been associated with several conditions (malignancies, autoimmune diseases, infections, use of drugs); moreover, a syndrome capable of inducing thromboembolic disease has recently been associated with the presence of these antibodies. The aim of this prospective study was to investigate the levels of APA in subjects affected by haematological malignancies undergoing allogeneic haematopoietic stem cell transplantation (ASCT). Between March 1996 and December 1997, 32 patients undergoing ASCT were studied prospectively until day +180 from transplant. The mean values of IgG and IgM anticardiolipin antibodies (ACA) increased in recipients of stem cells from an unrelated donor, and a statistically significant difference in ACA IgG mean value between unrelated and related transplanted patients was demonstrated between days +95 and +180. All of the subjects who received stem cells from an unrelated donor had APA levels higher than the mean normal value +3 SD vs. 35% of those receiving stem cells from a related donor (P

AB - Antiphospholipid antibodies (APA) are a family of autoimmune and alloimmune immunoglobulins recognizing protein-phospholipid complexes in in vitro laboratory test systems. These antibodies have been associated with several conditions (malignancies, autoimmune diseases, infections, use of drugs); moreover, a syndrome capable of inducing thromboembolic disease has recently been associated with the presence of these antibodies. The aim of this prospective study was to investigate the levels of APA in subjects affected by haematological malignancies undergoing allogeneic haematopoietic stem cell transplantation (ASCT). Between March 1996 and December 1997, 32 patients undergoing ASCT were studied prospectively until day +180 from transplant. The mean values of IgG and IgM anticardiolipin antibodies (ACA) increased in recipients of stem cells from an unrelated donor, and a statistically significant difference in ACA IgG mean value between unrelated and related transplanted patients was demonstrated between days +95 and +180. All of the subjects who received stem cells from an unrelated donor had APA levels higher than the mean normal value +3 SD vs. 35% of those receiving stem cells from a related donor (P

KW - Antiphospholipid antibodies

KW - B lymphocytes

KW - Cytomegalovirus infection

KW - Umbilical cord blood transplantation

KW - Unrelated allogeneic stem cell transplantation

UR - http://www.scopus.com/inward/record.url?scp=0033982435&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033982435&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2141.2000.01812.x

DO - 10.1046/j.1365-2141.2000.01812.x

M3 - Article

C2 - 10651735

AN - SCOPUS:0033982435

VL - 108

SP - 126

EP - 131

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 1

ER -