High levels of free haemoglobin in neonates and infants undergoing surgery on cardiopulmonary bypass

Zaccaria Ricci; Chiara Pezzella; Stefano Romagnoli; Francesca Iodice; Roberta Haiberger; Adriano Carotti; Paola Cogo

doi:10.1093/icvts/ivu129

High levels of free haemoglobin in neonates and infants undergoing surgery on cardiopulmonary bypass

Zaccaria Ricci, Chiara Pezzella, Stefano Romagnoli, Francesca Iodice, Roberta Haiberger, Adriano Carotti, Paola Cogo

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article

Abstract

OBJECTIVES Haemolysis is known to occur during surgery on cardiopulmonary bypass (CPB) and to be responsible for kidney injury. The aim of this study was to assess, in a cohort of infants, the reference levels of free haemoglobin (fHb) and their change over time postoperatively; the predicting variables of haemolysis in the intraoperative phase; and the association between fHb and renal function. METHODS A retrospective analysis in infants undergoing surgery on CPB was conducted. Children with preoperative renal dysfunction and need for extracorporeal membrane oxygenation support were excluded. fHb was sampled before and after CPB and on the first 2 postoperative days (POD). RESULTS Twenty-two patients with a median (interquartile) age of 111 (63-184) days and Aristotle score of 8 (6.4-9) were enrolled. fHb had a baseline value of 29 (24-41) mg/dl, peaked to 75 (65-109) mg/dl at CPB weaning and returned to 35 (30-55) mg/dl on POD 2 (P

Original language	English
Pages (from-to)	183-188
Number of pages	6
Journal	Interactive Cardiovascular and Thoracic Surgery
Volume	19
Issue number	2
DOIs	https://doi.org/10.1093/icvts/ivu129
Publication status	Published - 2014

Keywords

Acute kidney injury
Cardiopulmonary bypass
Free haemoglobin
Paediatric cardiac surgery

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Pulmonary and Respiratory Medicine
Surgery
Medicine(all)

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10.1093/icvts/ivu129

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Ricci, Z., Pezzella, C., Romagnoli, S., Iodice, F., Haiberger, R., Carotti, A., & Cogo, P. (2014). High levels of free haemoglobin in neonates and infants undergoing surgery on cardiopulmonary bypass. Interactive Cardiovascular and Thoracic Surgery, 19(2), 183-188. https://doi.org/10.1093/icvts/ivu129

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abstract = "OBJECTIVES Haemolysis is known to occur during surgery on cardiopulmonary bypass (CPB) and to be responsible for kidney injury. The aim of this study was to assess, in a cohort of infants, the reference levels of free haemoglobin (fHb) and their change over time postoperatively; the predicting variables of haemolysis in the intraoperative phase; and the association between fHb and renal function. METHODS A retrospective analysis in infants undergoing surgery on CPB was conducted. Children with preoperative renal dysfunction and need for extracorporeal membrane oxygenation support were excluded. fHb was sampled before and after CPB and on the first 2 postoperative days (POD). RESULTS Twenty-two patients with a median (interquartile) age of 111 (63-184) days and Aristotle score of 8 (6.4-9) were enrolled. fHb had a baseline value of 29 (24-41) mg/dl, peaked to 75 (65-109) mg/dl at CPB weaning and returned to 35 (30-55) mg/dl on POD 2 (P ",

keywords = "Acute kidney injury, Cardiopulmonary bypass, Free haemoglobin, Paediatric cardiac surgery",

author = "Zaccaria Ricci and Chiara Pezzella and Stefano Romagnoli and Francesca Iodice and Roberta Haiberger and Adriano Carotti and Paola Cogo",

year = "2014",

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AU - Ricci, Zaccaria

AU - Pezzella, Chiara

AU - Romagnoli, Stefano

AU - Iodice, Francesca

AU - Haiberger, Roberta

AU - Carotti, Adriano

AU - Cogo, Paola

PY - 2014

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N2 - OBJECTIVES Haemolysis is known to occur during surgery on cardiopulmonary bypass (CPB) and to be responsible for kidney injury. The aim of this study was to assess, in a cohort of infants, the reference levels of free haemoglobin (fHb) and their change over time postoperatively; the predicting variables of haemolysis in the intraoperative phase; and the association between fHb and renal function. METHODS A retrospective analysis in infants undergoing surgery on CPB was conducted. Children with preoperative renal dysfunction and need for extracorporeal membrane oxygenation support were excluded. fHb was sampled before and after CPB and on the first 2 postoperative days (POD). RESULTS Twenty-two patients with a median (interquartile) age of 111 (63-184) days and Aristotle score of 8 (6.4-9) were enrolled. fHb had a baseline value of 29 (24-41) mg/dl, peaked to 75 (65-109) mg/dl at CPB weaning and returned to 35 (30-55) mg/dl on POD 2 (P

AB - OBJECTIVES Haemolysis is known to occur during surgery on cardiopulmonary bypass (CPB) and to be responsible for kidney injury. The aim of this study was to assess, in a cohort of infants, the reference levels of free haemoglobin (fHb) and their change over time postoperatively; the predicting variables of haemolysis in the intraoperative phase; and the association between fHb and renal function. METHODS A retrospective analysis in infants undergoing surgery on CPB was conducted. Children with preoperative renal dysfunction and need for extracorporeal membrane oxygenation support were excluded. fHb was sampled before and after CPB and on the first 2 postoperative days (POD). RESULTS Twenty-two patients with a median (interquartile) age of 111 (63-184) days and Aristotle score of 8 (6.4-9) were enrolled. fHb had a baseline value of 29 (24-41) mg/dl, peaked to 75 (65-109) mg/dl at CPB weaning and returned to 35 (30-55) mg/dl on POD 2 (P

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