Abstract
OBJECTIVES Haemolysis is known to occur during surgery on cardiopulmonary bypass (CPB) and to be responsible for kidney injury. The aim of this study was to assess, in a cohort of infants, the reference levels of free haemoglobin (fHb) and their change over time postoperatively; the predicting variables of haemolysis in the intraoperative phase; and the association between fHb and renal function. METHODS A retrospective analysis in infants undergoing surgery on CPB was conducted. Children with preoperative renal dysfunction and need for extracorporeal membrane oxygenation support were excluded. fHb was sampled before and after CPB and on the first 2 postoperative days (POD). RESULTS Twenty-two patients with a median (interquartile) age of 111 (63-184) days and Aristotle score of 8 (6.4-9) were enrolled. fHb had a baseline value of 29 (24-41) mg/dl, peaked to 75 (65-109) mg/dl at CPB weaning and returned to 35 (30-55) mg/dl on POD 2 (P
| Original language | English |
|---|---|
| Pages (from-to) | 183-188 |
| Number of pages | 6 |
| Journal | Interactive Cardiovascular and Thoracic Surgery |
| Volume | 19 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 |
Fingerprint
Keywords
- Acute kidney injury
- Cardiopulmonary bypass
- Free haemoglobin
- Paediatric cardiac surgery
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Pulmonary and Respiratory Medicine
- Surgery
- Medicine(all)
Cite this
High levels of free haemoglobin in neonates and infants undergoing surgery on cardiopulmonary bypass. / Ricci, Zaccaria; Pezzella, Chiara; Romagnoli, Stefano; Iodice, Francesca; Haiberger, Roberta; Carotti, Adriano; Cogo, Paola.
In: Interactive Cardiovascular and Thoracic Surgery, Vol. 19, No. 2, 2014, p. 183-188.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High levels of free haemoglobin in neonates and infants undergoing surgery on cardiopulmonary bypass
AU - Ricci, Zaccaria
AU - Pezzella, Chiara
AU - Romagnoli, Stefano
AU - Iodice, Francesca
AU - Haiberger, Roberta
AU - Carotti, Adriano
AU - Cogo, Paola
PY - 2014
Y1 - 2014
N2 - OBJECTIVES Haemolysis is known to occur during surgery on cardiopulmonary bypass (CPB) and to be responsible for kidney injury. The aim of this study was to assess, in a cohort of infants, the reference levels of free haemoglobin (fHb) and their change over time postoperatively; the predicting variables of haemolysis in the intraoperative phase; and the association between fHb and renal function. METHODS A retrospective analysis in infants undergoing surgery on CPB was conducted. Children with preoperative renal dysfunction and need for extracorporeal membrane oxygenation support were excluded. fHb was sampled before and after CPB and on the first 2 postoperative days (POD). RESULTS Twenty-two patients with a median (interquartile) age of 111 (63-184) days and Aristotle score of 8 (6.4-9) were enrolled. fHb had a baseline value of 29 (24-41) mg/dl, peaked to 75 (65-109) mg/dl at CPB weaning and returned to 35 (30-55) mg/dl on POD 2 (P
AB - OBJECTIVES Haemolysis is known to occur during surgery on cardiopulmonary bypass (CPB) and to be responsible for kidney injury. The aim of this study was to assess, in a cohort of infants, the reference levels of free haemoglobin (fHb) and their change over time postoperatively; the predicting variables of haemolysis in the intraoperative phase; and the association between fHb and renal function. METHODS A retrospective analysis in infants undergoing surgery on CPB was conducted. Children with preoperative renal dysfunction and need for extracorporeal membrane oxygenation support were excluded. fHb was sampled before and after CPB and on the first 2 postoperative days (POD). RESULTS Twenty-two patients with a median (interquartile) age of 111 (63-184) days and Aristotle score of 8 (6.4-9) were enrolled. fHb had a baseline value of 29 (24-41) mg/dl, peaked to 75 (65-109) mg/dl at CPB weaning and returned to 35 (30-55) mg/dl on POD 2 (P
KW - Acute kidney injury
KW - Cardiopulmonary bypass
KW - Free haemoglobin
KW - Paediatric cardiac surgery
UR - http://www.scopus.com/inward/record.url?scp=84905656938&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905656938&partnerID=8YFLogxK
U2 - 10.1093/icvts/ivu129
DO - 10.1093/icvts/ivu129
M3 - Article
C2 - 24812332
AN - SCOPUS:84905656938
VL - 19
SP - 183
EP - 188
JO - Interactive Cardiovascular and Thoracic Surgery
JF - Interactive Cardiovascular and Thoracic Surgery
SN - 1569-9293
IS - 2
ER -