High levels of free haemoglobin in neonates and infants undergoing surgery on cardiopulmonary bypass

Zaccaria Ricci, Chiara Pezzella, Stefano Romagnoli, Francesca Iodice, Roberta Haiberger, Adriano Carotti, Paola Cogo

Research output: Contribution to journalArticle

Abstract

OBJECTIVES Haemolysis is known to occur during surgery on cardiopulmonary bypass (CPB) and to be responsible for kidney injury. The aim of this study was to assess, in a cohort of infants, the reference levels of free haemoglobin (fHb) and their change over time postoperatively; the predicting variables of haemolysis in the intraoperative phase; and the association between fHb and renal function. METHODS A retrospective analysis in infants undergoing surgery on CPB was conducted. Children with preoperative renal dysfunction and need for extracorporeal membrane oxygenation support were excluded. fHb was sampled before and after CPB and on the first 2 postoperative days (POD). RESULTS Twenty-two patients with a median (interquartile) age of 111 (63-184) days and Aristotle score of 8 (6.4-9) were enrolled. fHb had a baseline value of 29 (24-41) mg/dl, peaked to 75 (65-109) mg/dl at CPB weaning and returned to 35 (30-55) mg/dl on POD 2 (P

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalInteractive Cardiovascular and Thoracic Surgery
Volume19
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Acute kidney injury
  • Cardiopulmonary bypass
  • Free haemoglobin
  • Paediatric cardiac surgery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery
  • Medicine(all)

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