High levels of homocysteine, lipoprotein (a) and plasminogen activator inhibitor-1 are present in patients with abdominal aortic aneurysm

Francesco Sofi, Rossella Marcucci, Betti Giusti, Giovanni Pratesi, Barbara Lari, Ilaria Sestini, Patrizia Lo Sapio, Raffaele Pulli, Carlo Pratesi, Rosanna Abbate, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review

Abstract

Over the last few years,there has been increasing interest in the investigation of the pathogenesis of AAA, and a role for some novel risk factors, in particular thrombophilic risk factors, has been suggested. The aim of this study was to evaluate a number of thrombophilic parameters in a large group of patients with AAA. In 438 patients with AAA, and in 438 healthy subjects, selected to be comparable for age and gender with patients and without instrumental evidence of AAA, a pattern of thrombophilic parameters [homocysteine (Hcy), lipoprotein (a) [Lp(a)], plasminogen activator inhibitor-1 (PA1-1), anticardiolipin antibodies (ACA), MTHFR C677T polymorphism, prothrombin gene G20210A variant and Factor V Leiden mutation] has been evaluated. A significant difference for Hcy, PA1-1 and Lp(a) plasma levels has been observed between patients and controls. After adjustment for the traditional cardiovascular risk factors, a significant increased risk of having AAA has been observed for high levels of Hcy (OR:7.8;p

Original languageEnglish
Pages (from-to)1094-1098
Number of pages5
JournalThrombosis and Haemostasis
Volume94
Issue number5
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Abdominal aortic aneurysm
  • Emerging risk factor
  • Homocysteine
  • Lipoprotein (a)
  • Plasminogen activator inhibitor-1

ASJC Scopus subject areas

  • Hematology

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