High levels of transforming growth factor-alpha (TGF-α) mRNA may predict local relapses in early stage urinary bladder cancer

P. Gazzaniga, A. Gradilone, I. Silvestri, O. Gandini, M. Napolitano, R. Vercillo, A. Vincenzoni, M. Gallucci, L. Frati, A. M. Agliano'

Research output: Contribution to journalArticle

Abstract

Elevated expression of transforming growth factor-alpha (TGF-α) gene has been previously reported in some types of human neoplasms, but its role in the pathogenesis of bladder cancer has still not been investigated. In the present study, we analysed 28 samples of early stage bladder tumours for the presence of TGF-α mRNA using reverse transcription-polymerase chain reaction (RT-PCR). We detected TGF-α mRNA in 71% (20/28) of these samples. When we related the expression levels of TGF-α with local relapses of patients during a follow-up of 2 years, we found that a high TGF-α expression level in bladder cancer was significantly associated with local relapses in patients with early stage tumours. The appearance of early relapses in tumours with high TGF-α expression levels may suggest the existence of an additional marker in the prediction of local relapses in patients with superficial disease.

Original languageEnglish
Pages (from-to)934-936
Number of pages3
JournalEuropean Journal of Cancer
Volume34
Issue number6
DOIs
Publication statusPublished - May 1998

    Fingerprint

Keywords

  • Bladder cancer
  • Prognosis
  • TGF-α

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Gazzaniga, P., Gradilone, A., Silvestri, I., Gandini, O., Napolitano, M., Vercillo, R., Vincenzoni, A., Gallucci, M., Frati, L., & Agliano', A. M. (1998). High levels of transforming growth factor-alpha (TGF-α) mRNA may predict local relapses in early stage urinary bladder cancer. European Journal of Cancer, 34(6), 934-936. https://doi.org/10.1016/S0959-8049(97)10118-6