High lipoprotein (a) levels are associated with an increased risk of retinal vein occlusion

Francesco Sofi, Rossella Marcucci, Sandra Fedi, Barbara Giambene, Andrea Sodi, Ugo Menchini, Gian Franco Gensini, Rosanna Abbate, Domenico Prisco

Research output: Contribution to journalArticle

Abstract

Introduction: Retinal vein occlusion (RVO) is one of the most common retinal vascular disorders affecting ocular vessels. Few studies, with conflicting results and conducted in limited study populations, have hypothesised the role of high levels of lipoprotein (a) [Lp(a)] in the occurrence of RVO. The aim of this study was to investigate, in a large group of RVO patients, the role of such an emerging thrombophilic parameter on the pathogenesis of RVO. Materials and methods: We compared 262 patients [median age: 66 years (15-88); 122 M, 140 F] with 262 age- and sex-comparable healthy subjects. Results: Circulating concentrations of Lp(a) were found to be significantly different in patients when compared to healthy subjects [189 (60-1898). mg/L vs. 119.5 (6-1216). mg/L; p 300 mg/L were found to be associated with an increased risk of RVO (OR: 2.39, 95%CI 1.39-3.59; p 300 mg/L confirmed their role as a risk factor for RVO [first model, OR: 2.15 (95%CI 1.39-3.32), p=0.0001; second model, OR: 3.11 (95%CI 1.77-5.62), p

Original languageEnglish
Pages (from-to)278-281
Number of pages4
JournalAtherosclerosis
Volume210
Issue number1
DOIs
Publication statusPublished - May 2010

Keywords

  • Lipoprotein (a)
  • Retinal vein occlusion
  • Risk factor
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Sofi, F., Marcucci, R., Fedi, S., Giambene, B., Sodi, A., Menchini, U., Gensini, G. F., Abbate, R., & Prisco, D. (2010). High lipoprotein (a) levels are associated with an increased risk of retinal vein occlusion. Atherosclerosis, 210(1), 278-281. https://doi.org/10.1016/j.atherosclerosis.2009.11.006