High-mobility group A (HMGA) proteins and breast cancer

Silvia Peluso, Gennaro Chiappetta

Research output: Contribution to journalArticlepeer-review

Abstract

The high-mobility group A (HMGA) protein family includes HMGA1a, HMGA1b and HMGA1c, which are encoded by the same gene through alternative splicing, and the closely related HMGA2 protein. HMGA proteins have been found to be abundant in several malignant neoplasias, including colorectal, prostate, cervical, lung, thyroid and breast carcinoma. HMGA proteins can be ideal candidates for the identification of new prognosis and diagnosis factors with non-invasive methods. To provide some clarity regarding the abundance of articles on this topic, here we focus on the relationship between HMGA proteins and breast cancer and their clinical perspective in the development of new therapeutic strategies.

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalBreast Care
Volume5
Issue number2
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Blood samples
  • Breast cancer
  • HMGA
  • Prognostic factors

ASJC Scopus subject areas

  • Surgery
  • Oncology

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