High mobility group A1 expression correlates with the histological grade of human glial tumors

Giuseppe Donato, Josefina Martinez Hoyos, Andrea Amorosi, Lorenza Maltese, Angelo Lavano, Giorgio Volpentesta, Francesco Signorelli, Francesca Pentimalli, Pierlorenzo Pallante, Giuseppe Ferraro, Luigi Tucci, Cosma Damiano Signorelli, Giuseppe Viglietto, Alfredo Fusco

Research output: Contribution to journalArticle

Abstract

Glioblastoma is one of the most aggressive tumors in mankind with 50% of patients dying within the 1st year of diagnosis, and being refractory to conventional therapies. The aim of our work has been to analyse the expression of the HMGA1 proteins in human astrocytomas and glioblastomas in order to verify whether the detection of these proteins might be of some help in the diagnosis of these neoplasias. Here we report the analysis of 27 cases, including 12 astrocytomas and 15 glioblastomas, for HMGA1 expression. All the neoplastic samples showed positive staining even though the number of positive cells and the staining intensity was higher in glioblastomas compared to astrocytomas. Conversely, HMGA1 proteins were not detected in normal brain. Accordingly, expression of the hmga1 gene, analysed by RT-PCR, was higher in glioblastomas than in astrocytomas.

Original languageEnglish
Pages (from-to)1209-1213
Number of pages5
JournalOncology Reports
Volume11
Issue number6
Publication statusPublished - Jun 2004

Keywords

  • Astrocytoma
  • Glioblastoma
  • High mobility group A1
  • RT-PCR

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Donato, G., Hoyos, J. M., Amorosi, A., Maltese, L., Lavano, A., Volpentesta, G., Signorelli, F., Pentimalli, F., Pallante, P., Ferraro, G., Tucci, L., Signorelli, C. D., Viglietto, G., & Fusco, A. (2004). High mobility group A1 expression correlates with the histological grade of human glial tumors. Oncology Reports, 11(6), 1209-1213.