High-mobility group A1 proteins are overexpressed in human leukaemias

Giovanna Maria Pierantoni, Valter Agosti, Monica Fedele, Heather Bond, Irene Caliendo, Gennaro Chiappetta, Francesco Lo Coco, Fabrizio Pane, Maria Caterina Turco, Giovanni Morrone, Salvatore Venuta, Alfredo Fusco

Research output: Contribution to journalArticlepeer-review

Abstract

High-mobility group A (HMGA) proteins are non-histone nuclear proteins that bind DNA and several transcription factors. They are involved in the regulation of chromatin structure and function. HMGA protein expression is low in normal adult tissues, but abundant during embryonic development and in several human tumours. Rearrangements of the HMGA genes have been frequently detected in human benign tumours of mesenchymal origin, e.g. lipomas, lung hamartomas and uterine leiomiomas. HMGA proteins have been implicated in the control of cell growth and differentiation of the pre-adipocytic cell line 3T3-L1. In an attempt to better understand the role of HMGA1 proteins in haematological neoplasias and in the differentiation of haematopietic cells, we have investigated their expression in human leukaemias and in leukaemic cell lines induced to terminal differentiation. Here we report HMGA1 overexpression in most fresh human leukaemias of different origin and in several leukaemic cell lines. Moreover, differentiation of three cell lines towards the megakaryocytic phenotype was associated with HMGA1 protein induction, whereas induction of erythroid and monocytic differentiation generally resulted in reduced HMGA1 expression.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalBiochemical Journal
Volume372
Issue number1
DOIs
Publication statusPublished - May 15 2003

Keywords

  • HL60 cells
  • HMGA1
  • K562 cells
  • Leukaemia
  • Megakaryocytic differentiation

ASJC Scopus subject areas

  • Biochemistry

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