High mobility group box 1 protein, a cue for stem cell recruitment

Roberta Palumbo, Marco E. Bianchi

Research output: Contribution to journalArticlepeer-review


High mobility group box 1 (HMGB1) is a non-histone protein required to maintain chromatin architecture. Recent observations demonstrated that HMGB1 can also act as a cytokine to regulate different biological processes such as inflammation, cell migration and metastasis. We showed previously that HMGB1 can be released passively by cells that die in a traumatic and unprogrammed way, and can serve a signal of tissue damage. More recently, we showed that HMGB1 can recruit stem cells: HMGB1 induces stem cell transmigration through an endothelial barrier; moreover, when beads containing HMGB1 are implanted into healthy muscle, they recruit stem cells injected into the general circulation. The inflammatory and tissue-regenerating roles of HMGB1 may be strictly interconnected, and are discussed here.

Original languageEnglish
Pages (from-to)1165-1170
Number of pages6
JournalBiochemical Pharmacology
Issue number6
Publication statusPublished - Sep 15 2004


  • 1,1′-dioctadecyl-3,3,3′,3′- tetramethylindocarbocyanine perchlorate
  • DiI
  • high mobility group box 1
  • HMGB1
  • RAGE
  • receptor for advanced glycation end products
  • S.D.
  • standard deviation
  • TA
  • tibialis anterior
  • TNF
  • tumor necrosis factor
  • VEGF

ASJC Scopus subject areas

  • Pharmacology


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