High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases

Gennaro Chiappetta, Guidalberto Manfioletti, Francesca Pentimalli, Nobutsugu Abe, Maurizio Di Bonito, Maria Teresa Vento, Ada Giuliano, Monica Fedele, Giuseppe Viglietto, Massimo Santoro, Takashi Watanabe, Vincenzo Giancotti, Alfredo Fusco

Research output: Contribution to journalArticle

Abstract

HMGI(Y) proteins are overexpressed in experimental and human malignancies, including colon, prostate and thyroid carcinomas. To determine at which step of the carcinogenic process HMGI(Y) induction occurs, we analyzed the expression of the HMGI(Y) proteins in hyperplastic, preneoplastic and neoplastic tissues of colorectal origin by immunohisto-chemistry. All the colorectal carcinomas were HMG I(Y)-positive, whereas no expression was detected in normal colon mucosa tissue. HMGI(Y) expression in adenomas was closely correlated with the degree of cellular atypia. Only 2 of the 18 non-neoplastic polyps tested were HMGI(Y)-positive. These data indicate that HMGI(Y) protein induction is associated with the early stages of neoplastic transformation of colon cells and only rarely with colon cell hyperproliferation.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalInternational Journal of Cancer
Volume91
Issue number2
Publication statusPublished - Jan 15 2001

Keywords

  • Adenoma
  • Carcinoma
  • Chromatin
  • Colon
  • HMGI(Y)

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Chiappetta, G., Manfioletti, G., Pentimalli, F., Abe, N., Bonito, M. D., Vento, M. T., Giuliano, A., Fedele, M., Viglietto, G., Santoro, M., Watanabe, T., Giancotti, V., & Fusco, A. (2001). High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases. International Journal of Cancer, 91(2), 147-151.