High MUC2 immunohistochemical expression is a predictor of poor response to preoperative radiochemotherapy (RCT) in rectal adenocarcinoma

Andrea Ambrosini-Spaltro, Fabrizio Salvi, Rossella Miglio, Luciano Liguori, Carlo Fabbri, Antonio Piemontese, Ombretta Martelli, Giovanni P. Frezza, Maria P. Foschini

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study is to establish if mucoid differentiation is associated with responsiveness to preoperative radiochemotherapy (RCT) in rectal adenocarcinomas. Thirty-two patients with rectal adenocarcinomas were preoperatively treated with 44 to 46 Gy in 22 to 23 fractions and with 5-fluorouracil (200 to 225 mg/m) before surgery. Mucoid differentiation was searched for both in pre-RCT biopsies with anti-MUC2 antiserum and in postoperative specimens. To evaluate the responsiveness to preoperative RCT, a regression grading was used (grades 0 to 4). Statistical analysis showed a significant negative correlation between immunohistochemical expression of MUC2 in pre-RCT biopsies and regression grade in postoperative specimens (r=-0.529; P=0.002). A significant cutoff value of 60% of MUC2 positive neoplastic cells in pre-RCT biopsies was observed (P=0.018): 13 cases with more than 60% exhibited a poor response to RCT (grade 0 in 5/13, grade 1 in 4/13, grade 2 in 4/13), whereas 19 cases with less than 60% showed a better response to RCT (grade 1 in 6/19, grade 2 in 9/19, grade 3 in 3/19, grade 4 in 1/19).

Original languageEnglish
Pages (from-to)227-231
Number of pages5
JournalApplied Immunohistochemistry and Molecular Morphology
Volume16
Issue number3
DOIs
Publication statusPublished - May 2008

Keywords

  • Adenocarcinoma
  • Chemotherapy
  • MUC2
  • Mucoid
  • Radiotherapy
  • Rectum

ASJC Scopus subject areas

  • Anatomy
  • Medical Laboratory Technology

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