Abstract
Dopamine (DA) axons in the developing striatum cluster in discrete areas called "DA islands". During the third postnatal week, most DA islands are no-longer detectable and the DA innervation becomes uniform. In this study we explored the relationship between the pattern of DA innervation and the number of striatal tyrosine hydroxylase positive (TH+) cells during early postnatal development. By using dedicated stereology we found that the newborn striatum contains striatal TH+ cells, which cluster around newly sprouted DA axons. The number of these cells decreases when DA axons develop a full pattern of striatal innervation. This condition suggests a causal relationship between the amount of striatal DA innervation and the presence of striatal DA neurons. A better knowledge of the mechanisms regulating the ontogenesis of the nigrostriatal DA system may pave the way to strategies of neurorescue of the DA system.
| Original language | English |
|---|---|
| Pages (from-to) | 1375-1383 |
| Number of pages | 9 |
| Journal | Journal of Neural Transmission |
| Volume | 115 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2008 |
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Keywords
- Development of striatal TH+ neurons
- Dopamine islands
- Newborn striatum
- Parkinson's disease
- Striatal denervation
- Striatal dopamine cells
- Striatal innervation
ASJC Scopus subject areas
- Biological Psychiatry
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
Cite this
High number of striatal dopaminergic neurons during early postnatal development : Correlation analysis with dopaminergic fibers. / Busceti, Carla L.; Biagioni, Francesca; Mastroiacovo, Federica; Bucci, Domenico; Lenzi, Paola; Pasquali, Livia; Trabucco, Angela; Nicoletti, Ferdinando; Fornai, Francesco.
In: Journal of Neural Transmission, Vol. 115, No. 10, 10.2008, p. 1375-1383.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High number of striatal dopaminergic neurons during early postnatal development
T2 - Correlation analysis with dopaminergic fibers
AU - Busceti, Carla L.
AU - Biagioni, Francesca
AU - Mastroiacovo, Federica
AU - Bucci, Domenico
AU - Lenzi, Paola
AU - Pasquali, Livia
AU - Trabucco, Angela
AU - Nicoletti, Ferdinando
AU - Fornai, Francesco
PY - 2008/10
Y1 - 2008/10
N2 - Dopamine (DA) axons in the developing striatum cluster in discrete areas called "DA islands". During the third postnatal week, most DA islands are no-longer detectable and the DA innervation becomes uniform. In this study we explored the relationship between the pattern of DA innervation and the number of striatal tyrosine hydroxylase positive (TH+) cells during early postnatal development. By using dedicated stereology we found that the newborn striatum contains striatal TH+ cells, which cluster around newly sprouted DA axons. The number of these cells decreases when DA axons develop a full pattern of striatal innervation. This condition suggests a causal relationship between the amount of striatal DA innervation and the presence of striatal DA neurons. A better knowledge of the mechanisms regulating the ontogenesis of the nigrostriatal DA system may pave the way to strategies of neurorescue of the DA system.
AB - Dopamine (DA) axons in the developing striatum cluster in discrete areas called "DA islands". During the third postnatal week, most DA islands are no-longer detectable and the DA innervation becomes uniform. In this study we explored the relationship between the pattern of DA innervation and the number of striatal tyrosine hydroxylase positive (TH+) cells during early postnatal development. By using dedicated stereology we found that the newborn striatum contains striatal TH+ cells, which cluster around newly sprouted DA axons. The number of these cells decreases when DA axons develop a full pattern of striatal innervation. This condition suggests a causal relationship between the amount of striatal DA innervation and the presence of striatal DA neurons. A better knowledge of the mechanisms regulating the ontogenesis of the nigrostriatal DA system may pave the way to strategies of neurorescue of the DA system.
KW - Development of striatal TH+ neurons
KW - Dopamine islands
KW - Newborn striatum
KW - Parkinson's disease
KW - Striatal denervation
KW - Striatal dopamine cells
KW - Striatal innervation
UR - http://www.scopus.com/inward/record.url?scp=52449087985&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52449087985&partnerID=8YFLogxK
U2 - 10.1007/s00702-008-0112-x
DO - 10.1007/s00702-008-0112-x
M3 - Article
VL - 115
SP - 1375
EP - 1383
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
SN - 0300-9564
IS - 10
ER -