High number of striatal dopaminergic neurons during early postnatal development

Correlation analysis with dopaminergic fibers

Carla L. Busceti, Francesca Biagioni, Federica Mastroiacovo, Domenico Bucci, Paola Lenzi, Livia Pasquali, Angela Trabucco, Ferdinando Nicoletti, Francesco Fornai

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Dopamine (DA) axons in the developing striatum cluster in discrete areas called "DA islands". During the third postnatal week, most DA islands are no-longer detectable and the DA innervation becomes uniform. In this study we explored the relationship between the pattern of DA innervation and the number of striatal tyrosine hydroxylase positive (TH+) cells during early postnatal development. By using dedicated stereology we found that the newborn striatum contains striatal TH+ cells, which cluster around newly sprouted DA axons. The number of these cells decreases when DA axons develop a full pattern of striatal innervation. This condition suggests a causal relationship between the amount of striatal DA innervation and the presence of striatal DA neurons. A better knowledge of the mechanisms regulating the ontogenesis of the nigrostriatal DA system may pave the way to strategies of neurorescue of the DA system.

Original languageEnglish
Pages (from-to)1375-1383
Number of pages9
JournalJournal of Neural Transmission
Volume115
Issue number10
DOIs
Publication statusPublished - Oct 2008

Fingerprint

Corpus Striatum
Dopaminergic Neurons
Dopamine
Axons
Islands
Tyrosine 3-Monooxygenase
Cell Count

Keywords

  • Development of striatal TH+ neurons
  • Dopamine islands
  • Newborn striatum
  • Parkinson's disease
  • Striatal denervation
  • Striatal dopamine cells
  • Striatal innervation

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

High number of striatal dopaminergic neurons during early postnatal development : Correlation analysis with dopaminergic fibers. / Busceti, Carla L.; Biagioni, Francesca; Mastroiacovo, Federica; Bucci, Domenico; Lenzi, Paola; Pasquali, Livia; Trabucco, Angela; Nicoletti, Ferdinando; Fornai, Francesco.

In: Journal of Neural Transmission, Vol. 115, No. 10, 10.2008, p. 1375-1383.

Research output: Contribution to journalArticle

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