High number of striatal dopaminergic neurons during early postnatal development: Correlation analysis with dopaminergic fibers

Carla L. Busceti, Francesca Biagioni, Federica Mastroiacovo, Domenico Bucci, Paola Lenzi, Livia Pasquali, Angela Trabucco, Ferdinando Nicoletti, Francesco Fornai

Research output: Contribution to journalArticlepeer-review

Abstract

Dopamine (DA) axons in the developing striatum cluster in discrete areas called "DA islands". During the third postnatal week, most DA islands are no-longer detectable and the DA innervation becomes uniform. In this study we explored the relationship between the pattern of DA innervation and the number of striatal tyrosine hydroxylase positive (TH+) cells during early postnatal development. By using dedicated stereology we found that the newborn striatum contains striatal TH+ cells, which cluster around newly sprouted DA axons. The number of these cells decreases when DA axons develop a full pattern of striatal innervation. This condition suggests a causal relationship between the amount of striatal DA innervation and the presence of striatal DA neurons. A better knowledge of the mechanisms regulating the ontogenesis of the nigrostriatal DA system may pave the way to strategies of neurorescue of the DA system.

Original languageEnglish
Pages (from-to)1375-1383
Number of pages9
JournalJournal of Neural Transmission
Volume115
Issue number10
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Development of striatal TH+ neurons
  • Dopamine islands
  • Newborn striatum
  • Parkinson's disease
  • Striatal denervation
  • Striatal dopamine cells
  • Striatal innervation

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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