TY - JOUR
T1 - High number of striatal dopaminergic neurons during early postnatal development
T2 - Correlation analysis with dopaminergic fibers
AU - Busceti, Carla L.
AU - Biagioni, Francesca
AU - Mastroiacovo, Federica
AU - Bucci, Domenico
AU - Lenzi, Paola
AU - Pasquali, Livia
AU - Trabucco, Angela
AU - Nicoletti, Ferdinando
AU - Fornai, Francesco
PY - 2008/10
Y1 - 2008/10
N2 - Dopamine (DA) axons in the developing striatum cluster in discrete areas called "DA islands". During the third postnatal week, most DA islands are no-longer detectable and the DA innervation becomes uniform. In this study we explored the relationship between the pattern of DA innervation and the number of striatal tyrosine hydroxylase positive (TH+) cells during early postnatal development. By using dedicated stereology we found that the newborn striatum contains striatal TH+ cells, which cluster around newly sprouted DA axons. The number of these cells decreases when DA axons develop a full pattern of striatal innervation. This condition suggests a causal relationship between the amount of striatal DA innervation and the presence of striatal DA neurons. A better knowledge of the mechanisms regulating the ontogenesis of the nigrostriatal DA system may pave the way to strategies of neurorescue of the DA system.
AB - Dopamine (DA) axons in the developing striatum cluster in discrete areas called "DA islands". During the third postnatal week, most DA islands are no-longer detectable and the DA innervation becomes uniform. In this study we explored the relationship between the pattern of DA innervation and the number of striatal tyrosine hydroxylase positive (TH+) cells during early postnatal development. By using dedicated stereology we found that the newborn striatum contains striatal TH+ cells, which cluster around newly sprouted DA axons. The number of these cells decreases when DA axons develop a full pattern of striatal innervation. This condition suggests a causal relationship between the amount of striatal DA innervation and the presence of striatal DA neurons. A better knowledge of the mechanisms regulating the ontogenesis of the nigrostriatal DA system may pave the way to strategies of neurorescue of the DA system.
KW - Development of striatal TH+ neurons
KW - Dopamine islands
KW - Newborn striatum
KW - Parkinson's disease
KW - Striatal denervation
KW - Striatal dopamine cells
KW - Striatal innervation
UR - http://www.scopus.com/inward/record.url?scp=52449087985&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52449087985&partnerID=8YFLogxK
U2 - 10.1007/s00702-008-0112-x
DO - 10.1007/s00702-008-0112-x
M3 - Article
C2 - 18758687
AN - SCOPUS:52449087985
VL - 115
SP - 1375
EP - 1383
JO - Journal of Neuro-Visceral Relations
JF - Journal of Neuro-Visceral Relations
SN - 0375-9245
IS - 10
ER -