Abstract
Three chiral stationary phases, obtained by grafting silica gel with (-)-trans-1,2-cyclohexanediamine, were studied for the resolution of alpha -amino acids by ligand-exchange chromatography. The packings were prepared by bonding the chiral ligand to silica gel via different hydrocarbon spacers. Separation of the optical isomers was accomplished by eluents containing a constant concentration of copper(II) acetate (0. 05mM). The elution sequence of amino acids was found to be dependent on the grafting reaction selected to prepare the chiral packings.
| Original language | English |
|---|---|
| Pages (from-to) | 401-404 |
| Number of pages | 4 |
| Journal | HRC & CC. Journal of high resolution chromatography & chromatography communications |
| Volume | 11 |
| Issue number | 5 |
| Publication status | Published - May 1988 |
ASJC Scopus subject areas
- Engineering(all)
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Carunchio, V., Messina, A., Sinibaldi, M., & Fanali, S. (1988). HIGH-PERFORMANCE LIGAND-EXCHANGE CHROMATOGRAPHY OF AMINO ACIDS ON CHIRAL STATIONARY PHASES. HRC & CC. Journal of high resolution chromatography & chromatography communications, 11(5), 401-404.