High-performance ligand exchange chromatography on chiral diamine-bonded silica gel

C. Corradini; F. Federici; M. Sinibaldi; A. Messina

doi:10.1007/BF02312886

High-performance ligand exchange chromatography on chiral diamine-bonded silica gel

C. Corradini, F. Federici, M. Sinibaldi, A. Messina

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

The resolution of racemates on chiral chemically bonded silica gel by high-performance ligand-exchange chromatography is described. The stationary phase was prepared by bonding (-) trans 1,2 cyclohexanediamine to silica gel through the coupling agent 3-glycidoxypropyl silane. The resolution of several α-amino acids and of compounds of pharmaceutical interest is reported.

Original language	English
Pages (from-to)	118-120
Number of pages	3
Journal	Chromatographia
Volume	23
Issue number	2
DOIs	https://doi.org/10.1007/BF02312886
Publication status	Published - Feb 1987

Keywords

Amino acids
Chiral bonded phase
Column liquid chromatography
Ligand-exchange chromatography
Racemate resolution

ASJC Scopus subject areas

Analytical Chemistry
Clinical Biochemistry

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title = "High-performance ligand exchange chromatography on chiral diamine-bonded silica gel",

abstract = "The resolution of racemates on chiral chemically bonded silica gel by high-performance ligand-exchange chromatography is described. The stationary phase was prepared by bonding (-) trans 1,2 cyclohexanediamine to silica gel through the coupling agent 3-glycidoxypropyl silane. The resolution of several α-amino acids and of compounds of pharmaceutical interest is reported.",

keywords = "Amino acids, Chiral bonded phase, Column liquid chromatography, Ligand-exchange chromatography, Racemate resolution",

author = "C. Corradini and F. Federici and M. Sinibaldi and A. Messina",

year = "1987",

month = feb,

doi = "10.1007/BF02312886",

language = "English",

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journal = "Chromatographia",

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AU - Corradini, C.

AU - Federici, F.

AU - Sinibaldi, M.

AU - Messina, A.

PY - 1987/2

Y1 - 1987/2

N2 - The resolution of racemates on chiral chemically bonded silica gel by high-performance ligand-exchange chromatography is described. The stationary phase was prepared by bonding (-) trans 1,2 cyclohexanediamine to silica gel through the coupling agent 3-glycidoxypropyl silane. The resolution of several α-amino acids and of compounds of pharmaceutical interest is reported.

AB - The resolution of racemates on chiral chemically bonded silica gel by high-performance ligand-exchange chromatography is described. The stationary phase was prepared by bonding (-) trans 1,2 cyclohexanediamine to silica gel through the coupling agent 3-glycidoxypropyl silane. The resolution of several α-amino acids and of compounds of pharmaceutical interest is reported.

KW - Amino acids

KW - Chiral bonded phase

KW - Column liquid chromatography

KW - Ligand-exchange chromatography

KW - Racemate resolution

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JF - Chromatographia

SN - 0009-5893

IS - 2

ER -

High-performance ligand exchange chromatography on chiral diamine-bonded silica gel

Abstract

Keywords

ASJC Scopus subject areas

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