High-performance ligand exchange chromatography on chiral diamine-bonded silica gel

C. Corradini, F. Federici, M. Sinibaldi, A. Messina

Research output: Contribution to journalArticlepeer-review


The resolution of racemates on chiral chemically bonded silica gel by high-performance ligand-exchange chromatography is described. The stationary phase was prepared by bonding (-) trans 1,2 cyclohexanediamine to silica gel through the coupling agent 3-glycidoxypropyl silane. The resolution of several α-amino acids and of compounds of pharmaceutical interest is reported.

Original languageEnglish
Pages (from-to)118-120
Number of pages3
Issue number2
Publication statusPublished - Feb 1987


  • Amino acids
  • Chiral bonded phase
  • Column liquid chromatography
  • Ligand-exchange chromatography
  • Racemate resolution

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry


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