High-performance liquid chromatographic resolution of enantiomers on chiral epoxy polymer-coated silica gel

A. Messina, I. Nicoletti, M. G. Quaglia-Strano, M. Sinibaldi

Research output: Contribution to journalArticle

Abstract

A chiral stationary phase for the separation of some D-and L-amino acid derivatives using a new resolving agent is described. The enantiomeric resolution was accomplished by normal phase high-performance liquid chromatography. The support was easily prepared by coating an epoxy polymer of L-valinamide on aminopropylsilanized macroporous silica. The influence of subambient temperatures on the enantioselectivity was also examined.

Original languageEnglish
Pages (from-to)477-480
Number of pages4
JournalChromatographia
Volume28
Issue number9-10
DOIs
Publication statusPublished - Nov 1989

Keywords

  • Chiral stationary phase
  • Column liquid chromatography
  • Enantioseparation by HPLC
  • Resolution of amino acid derivatives

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

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