TY - JOUR
T1 - High platelet count at diagnosis is a protective factor for thrombosis in patients with essential thrombocythemia
AU - Latagliata, Roberto
AU - Montanaro, Marco
AU - Cedrone, Michele
AU - Di Veroli, Ambra
AU - Spirito, Francesca
AU - Santoro, Cristina
AU - Leonetti Crescenzi, Sabrina
AU - Porrini, Raffaele
AU - Di Giandomenico, Jonny
AU - Villivà, Nicoletta
AU - Spadea, Antonio
AU - Rago, Angela
AU - De Gregoris, Cinzia
AU - Romano, Atelda
AU - Anaclerico, Barbara
AU - De Muro, Marianna
AU - Felici, Stefano
AU - Breccia, Massimo
AU - Montefusco, Enrico
AU - Bagnato, Antonino
AU - Cimino, Giuseppe
AU - Majolino, Ignazio
AU - Mazzucconi, Maria Gabriella
AU - Alimena, Giuliana
AU - Andriani, Alessandro
AU - Gruppo Laziale, SMPC Ph1
N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.
PY - 2017/8
Y1 - 2017/8
N2 - To assess the role of platelet (PLT) count for thrombotic complications in Essential Thrombocythemia (ET), 1201 patients followed in 11 Hematological centers in the Latium region were retrospectively evaluated. At multivariate analysis, the following factors at diagnosis were predictive for a worse Thrombosis-free Survival (TFS): the occurrence of previous thrombotic events (p=0.0004), age>60years (p=0.0044), spleen enlargement (p=0.042) and a lower PLT count (p=0.03). Receiver Operating Characteristic (ROC) analyses based on thrombotic events during follow-up identified a baseline platelet count of 944×109/l as the best predictive threshold: thrombotic events were 40/384 (10.4%) in patients with PLT count >944×109/l and 109/817 (13.3%) in patients with PLT count <944×109/l, respectively (p=0.04). Patients with PLT count <944×109/l were older (median age 60.4years. vs 57.1years., p=0.016), had a lower median WBC count (8.8×109/l vs 10.6×109/l, p<0.0001), a higher median Hb level (14.1g/dl vs 13.6g/dl, p<0.0001) and a higher rate of JAK-2-V617F positivity (67.2% vs 41.6%, p<0.0001); no difference was observed as to thrombotic events before diagnosis, spleen enlargement and concomitant Cardiovascular Risk Factors. In conclusion, our results confirm the protective role for thrombosis of an high PLT count at diagnosis. The older age and the higher rate of JAK-2 V617F positivity in the group of patients with a baseline lower PLT count could in part be responsible of this counterintuitive finding.
AB - To assess the role of platelet (PLT) count for thrombotic complications in Essential Thrombocythemia (ET), 1201 patients followed in 11 Hematological centers in the Latium region were retrospectively evaluated. At multivariate analysis, the following factors at diagnosis were predictive for a worse Thrombosis-free Survival (TFS): the occurrence of previous thrombotic events (p=0.0004), age>60years (p=0.0044), spleen enlargement (p=0.042) and a lower PLT count (p=0.03). Receiver Operating Characteristic (ROC) analyses based on thrombotic events during follow-up identified a baseline platelet count of 944×109/l as the best predictive threshold: thrombotic events were 40/384 (10.4%) in patients with PLT count >944×109/l and 109/817 (13.3%) in patients with PLT count <944×109/l, respectively (p=0.04). Patients with PLT count <944×109/l were older (median age 60.4years. vs 57.1years., p=0.016), had a lower median WBC count (8.8×109/l vs 10.6×109/l, p<0.0001), a higher median Hb level (14.1g/dl vs 13.6g/dl, p<0.0001) and a higher rate of JAK-2-V617F positivity (67.2% vs 41.6%, p<0.0001); no difference was observed as to thrombotic events before diagnosis, spleen enlargement and concomitant Cardiovascular Risk Factors. In conclusion, our results confirm the protective role for thrombosis of an high PLT count at diagnosis. The older age and the higher rate of JAK-2 V617F positivity in the group of patients with a baseline lower PLT count could in part be responsible of this counterintuitive finding.
KW - Journal Article
U2 - 10.1016/j.thromres.2017.06.023
DO - 10.1016/j.thromres.2017.06.023
M3 - Article
C2 - 28662484
VL - 156
SP - 168
EP - 171
JO - Thrombosis Research
JF - Thrombosis Research
SN - 0049-3848
ER -