High platelet turnover and reactivity in renal transplant recipients patients

Francesca Cesari, Rossella Marcucci, Anna Maria Gori, Roberto Caporale, Alessandra Fanelli, Rita Paniccia, Maria Zanazzi, Elisabetta Bertoni, Aida Larti, Maurizio Salvadori, Gian Franco Gensini, Rosanna Abbate

Research output: Contribution to journalArticle

Abstract

Renal transplant recipients (RTRs) patients are at increased risk of cardiovascular morbidity and mortality. We aimed this study to assess reticulated platelets (RP), platelet reactivity and von Willebrand factor (vWF) levels in RTRs patients. In 150 RTRs patients [84 (56%) not on acetylsalicylic acid (ASA) treatment, group A; 66 (44%) on ASA 100 mg treatment, group B] and in 60 healthy control subjects, RP were measured by a Sysmex XE-2100 and were expressed as the percentage of RP of the total optical platelet count (immature platelet fraction; IPF), as the percentage of RP highly fluorescent (H-IPF) and as the absolute number of RP (IPF#). Platelet function was assessed by optical aggregometry (PA) induced by 1 mmol arachidonic acid (AA-PA), 2 and 10 μM ADP (ADP2-PA and ADP10-PA) and 2 μg/ml collagen (Coll-PA). vWF levels were measured by using a miniVidas analyser. Group A and group B showed significant higher values of RP than controls. At a multiple linear regression analysis IPF and IPF# were significantly and positively related to collagen-PA. By analysing group B according to residual platelet reactivity (RPR), we observed a significant higher number of RP among patients with RPR by collagen. Moreover at a multiple logistic regression analysis, IPF# significantly affected the risk of having a RPR by collagen. With regard to vWF, RTRs patients showed higher levels than control subjects. We documented a higher platelet turn-over in both groups of RTRs patients and increased platelet reactivity in RTRs patients not on ASA therapy than controls.

Original languageEnglish
Pages (from-to)804-810
Number of pages7
JournalThrombosis and Haemostasis
Volume104
Issue number4
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Blood Platelets
Kidney
von Willebrand Factor
Collagen
Platelet Count
Aspirin
Transplant Recipients
Regression Analysis
Arachidonic Acid
Adenosine Diphosphate
Linear Models
Healthy Volunteers
Therapeutics
Logistic Models
Morbidity
Mortality

Keywords

  • Platelet reactivity
  • Renal transplantation
  • Reticulated platelets

ASJC Scopus subject areas

  • Hematology

Cite this

Cesari, F., Marcucci, R., Gori, A. M., Caporale, R., Fanelli, A., Paniccia, R., ... Abbate, R. (2010). High platelet turnover and reactivity in renal transplant recipients patients. Thrombosis and Haemostasis, 104(4), 804-810. https://doi.org/10.1160/TH10-02-0124

High platelet turnover and reactivity in renal transplant recipients patients. / Cesari, Francesca; Marcucci, Rossella; Gori, Anna Maria; Caporale, Roberto; Fanelli, Alessandra; Paniccia, Rita; Zanazzi, Maria; Bertoni, Elisabetta; Larti, Aida; Salvadori, Maurizio; Gensini, Gian Franco; Abbate, Rosanna.

In: Thrombosis and Haemostasis, Vol. 104, No. 4, 10.2010, p. 804-810.

Research output: Contribution to journalArticle

Cesari, F, Marcucci, R, Gori, AM, Caporale, R, Fanelli, A, Paniccia, R, Zanazzi, M, Bertoni, E, Larti, A, Salvadori, M, Gensini, GF & Abbate, R 2010, 'High platelet turnover and reactivity in renal transplant recipients patients', Thrombosis and Haemostasis, vol. 104, no. 4, pp. 804-810. https://doi.org/10.1160/TH10-02-0124
Cesari F, Marcucci R, Gori AM, Caporale R, Fanelli A, Paniccia R et al. High platelet turnover and reactivity in renal transplant recipients patients. Thrombosis and Haemostasis. 2010 Oct;104(4):804-810. https://doi.org/10.1160/TH10-02-0124
Cesari, Francesca ; Marcucci, Rossella ; Gori, Anna Maria ; Caporale, Roberto ; Fanelli, Alessandra ; Paniccia, Rita ; Zanazzi, Maria ; Bertoni, Elisabetta ; Larti, Aida ; Salvadori, Maurizio ; Gensini, Gian Franco ; Abbate, Rosanna. / High platelet turnover and reactivity in renal transplant recipients patients. In: Thrombosis and Haemostasis. 2010 ; Vol. 104, No. 4. pp. 804-810.
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