High Pre-Transplant Serum Levels of CXCL10 Predict Early Renal Allograft Failure

Elisabetta Bertoni; P. Romagnani; M. Rotondi; A. Rosati; A. Buonamano; L. Lasagni; E. Lazzeri; F. Pradella; V. Fossombroni; G. La Villa; M. Serio; M. Salvadori

High Pre-Transplant Serum Levels of CXCL10 Predict Early Renal Allograft Failure

Elisabetta Bertoni, P. Romagnani, M. Rotondi, A. Rosati, A. Buonamano, L. Lasagni, E. Lazzeri, F. Pradella, V. Fossombroni, G. La Villa, M. Serio, M. Salvadori

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The chemokine CXCL10 is a potent chemoattractant for activated lymphocytes and dendritic cells and mediates vascular injury by inducing intimal hyperplasia and inhibition of endothelial cell growth. Neutralisation of CXCL10 prolongs allograft survival and transplant knock-out models have shown that this chemokine is required for the initiation and development of graft failure due to both acute and chronic rejection. In the present study, we investigated whether pre-transplant CXCL10 serum levels may predict the recipient risk of graft rejection and transplant failure. Methods: Pre-transplant sera of 299 cadaver kidney graft recipients were tested retrospectively for serum CXCL10 levels by a quantitative sandwich immunoassay. Results: Kidney graft recipients with normally functioning grafts showed higher pre-transplant CXCL10 serum levels than healthy controls, but significantly lower than patients who experienced graft failure (133.47±119.6 vs. 182.8±155.01 pg/ml; p

Original language	English
Pages (from-to)	91-96
Number of pages	6
Journal	Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft
Volume	15
Issue number	2
Publication status	Published - 2003

Keywords

Allograft failure
Allograft rejection
Chemokines
IP-10
Renal transplantation

ASJC Scopus subject areas

Transplantation
Immunology and Allergy

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High Pre-Transplant Serum Levels of CXCL10 Predict Early Renal Allograft Failure. / Bertoni, Elisabetta; Romagnani, P.; Rotondi, M.; Rosati, A.; Buonamano, A.; Lasagni, L.; Lazzeri, E.; Pradella, F.; Fossombroni, V.; La Villa, G.; Serio, M.; Salvadori, M.

In: Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft, Vol. 15, No. 2, 2003, p. 91-96.

Research output: Contribution to journal › Article › peer-review

Bertoni, Elisabetta ; Romagnani, P. ; Rotondi, M. ; Rosati, A. ; Buonamano, A. ; Lasagni, L. ; Lazzeri, E. ; Pradella, F. ; Fossombroni, V. ; La Villa, G. ; Serio, M. ; Salvadori, M. / High Pre-Transplant Serum Levels of CXCL10 Predict Early Renal Allograft Failure. In: Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft. 2003 ; Vol. 15, No. 2. pp. 91-96.

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abstract = "Background: The chemokine CXCL10 is a potent chemoattractant for activated lymphocytes and dendritic cells and mediates vascular injury by inducing intimal hyperplasia and inhibition of endothelial cell growth. Neutralisation of CXCL10 prolongs allograft survival and transplant knock-out models have shown that this chemokine is required for the initiation and development of graft failure due to both acute and chronic rejection. In the present study, we investigated whether pre-transplant CXCL10 serum levels may predict the recipient risk of graft rejection and transplant failure. Methods: Pre-transplant sera of 299 cadaver kidney graft recipients were tested retrospectively for serum CXCL10 levels by a quantitative sandwich immunoassay. Results: Kidney graft recipients with normally functioning grafts showed higher pre-transplant CXCL10 serum levels than healthy controls, but significantly lower than patients who experienced graft failure (133.47±119.6 vs. 182.8±155.01 pg/ml; p",

keywords = "Allograft failure, Allograft rejection, Chemokines, IP-10, Renal transplantation",

author = "Elisabetta Bertoni and P. Romagnani and M. Rotondi and A. Rosati and A. Buonamano and L. Lasagni and E. Lazzeri and F. Pradella and V. Fossombroni and {La Villa}, G. and M. Serio and M. Salvadori",

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T1 - High Pre-Transplant Serum Levels of CXCL10 Predict Early Renal Allograft Failure

AU - Bertoni, Elisabetta

AU - Romagnani, P.

AU - Rotondi, M.

AU - Rosati, A.

AU - Buonamano, A.

AU - Lasagni, L.

AU - Lazzeri, E.

AU - Pradella, F.

AU - Fossombroni, V.

AU - La Villa, G.

AU - Serio, M.

AU - Salvadori, M.

PY - 2003

Y1 - 2003

N2 - Background: The chemokine CXCL10 is a potent chemoattractant for activated lymphocytes and dendritic cells and mediates vascular injury by inducing intimal hyperplasia and inhibition of endothelial cell growth. Neutralisation of CXCL10 prolongs allograft survival and transplant knock-out models have shown that this chemokine is required for the initiation and development of graft failure due to both acute and chronic rejection. In the present study, we investigated whether pre-transplant CXCL10 serum levels may predict the recipient risk of graft rejection and transplant failure. Methods: Pre-transplant sera of 299 cadaver kidney graft recipients were tested retrospectively for serum CXCL10 levels by a quantitative sandwich immunoassay. Results: Kidney graft recipients with normally functioning grafts showed higher pre-transplant CXCL10 serum levels than healthy controls, but significantly lower than patients who experienced graft failure (133.47±119.6 vs. 182.8±155.01 pg/ml; p

AB - Background: The chemokine CXCL10 is a potent chemoattractant for activated lymphocytes and dendritic cells and mediates vascular injury by inducing intimal hyperplasia and inhibition of endothelial cell growth. Neutralisation of CXCL10 prolongs allograft survival and transplant knock-out models have shown that this chemokine is required for the initiation and development of graft failure due to both acute and chronic rejection. In the present study, we investigated whether pre-transplant CXCL10 serum levels may predict the recipient risk of graft rejection and transplant failure. Methods: Pre-transplant sera of 299 cadaver kidney graft recipients were tested retrospectively for serum CXCL10 levels by a quantitative sandwich immunoassay. Results: Kidney graft recipients with normally functioning grafts showed higher pre-transplant CXCL10 serum levels than healthy controls, but significantly lower than patients who experienced graft failure (133.47±119.6 vs. 182.8±155.01 pg/ml; p

KW - Allograft failure

KW - Allograft rejection

KW - Chemokines

KW - IP-10

KW - Renal transplantation

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