High pretransplant serum levels of CXCL10/IP-10 are related to increased risk of renal allograft failure

Mario Rotondi, Alberto Rosati, Andrea Buonamano, Laura Lasagni, Elena Lazzeri, Fabio Pradella, Vittorio Fossombroni, Calogero Cirami, Francesco Liotta, Giorgio La Villa, Mario Serio, Elisabetta Bertoni, Maurizio Salvadori, Paola Romagnani

Research output: Contribution to journalArticlepeer-review

Abstract

In experimental models, the chemokine CXCL10/IP-10 is required for graft failure owing to both acute and chronic rejection. In the present study, pretransplantation sera from 316 cadaver kidney graft recipients were tested for serum CXCL10 and CCL22/MDC levels by an ELISA assay. Kidney graft recipients with normally functioning grafts showed significantly lower serum CXCL10 levels than patients who experienced graft failure, whereas no differences for serum CCL22 levels were observed. After the assignment of all patients to four groups according to serum CXCL10 levels, the death-censored survival rates of grafts were 97.5%, 93.6%, 89.7%, 78.7% (p = 0.0006) at 5 years, while no influence was observed on patient survival. Accordingly, patients with the highest CXCL10 levels showed an increased frequency and severity of rejection episodes. Serum C-reactive protein (CRP) level was also assayed in the same samples. Increase of serum CRP levels represented a predictive parameter for death, but not for graft failure. Multivariate analysis demonstrated that among the analyzed variables, CXCL10 had the highest predictive power of graft loss (RR 2.787). Thus, measurement of pretransplant serum CXCL10 levels might represent a clinically useful parameter to identify subjects who are at high risk of severe rejection and graft failure.

Original languageEnglish
Pages (from-to)1466-1474
Number of pages9
JournalAmerican Journal of Transplantation
Volume4
Issue number9
DOIs
Publication statusPublished - Sep 2004

Keywords

  • CXCR3
  • Graft failure
  • Graft outcome
  • IP-10
  • Rejection

ASJC Scopus subject areas

  • Immunology

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