TY - JOUR
T1 - High prevalence, low pathogenicity of hepatitis G virus in kidney transplant recipients
AU - De Filippi, F.
AU - Lampertico, P.
AU - Soffredini, R.
AU - Rumi, M. G.
AU - Lunghi, G.
AU - Aroldi, A.
AU - Tarantino, A.
AU - Ponticelli, C.
AU - Colombo, M.
PY - 2001
Y1 - 2001
N2 - Background. Prevalence and pathogenicity of hepatitis G virus infection in long-term renal transplant recipients, are not fully known. Aim. To evaluate long-term impact of HGV infection on liver disease of renal transplanted patients. Patients and Methods. A total of 155 hepatitis B surface antigen negative kidney transplant recipients, followed for a mean of 11 years after renal transplantation, were studied. Of these 48 (31%) patients had persistently elevated serum aminotransferase values. Frozen serum samples were tested for HGV-RNA and HCV-RNA by nested reverse transcribed polymerase chain reaction, and for anti-hepatitis G virus and anti-hepatitis C virus by enzyme-linked immunosorbent assay. Hepatitis C virus-RNA was typed by a line probe assay and quantified by a branched DNA signal amplification assay. Results. Hepatitis G virus-RNA was detected in 37 (24%) patients and anti-hepatitis G virus in another 26 (17%). Seventy (45%) patients had serum anti-hepatitis C virus and 63 of these (90%) had serum hepatitis C virus-RNA. Hepatitis G virus-RNA positive and negative patients were similar in terms of age, sex, duration of dialysis, rate of transfusion, chronic liver disease, rate of hepatitis C virus infection and immunosuppressive therapy. Fifteen (41%) hepatitis G virus-RNA seropositive patients were hepatitis C virus co-infected. Hepatitis C virus-RNA levels were significantly lower in the 15 hepatitis C virus/hepatitis G virus co-infected patients than in the 48 patients with hepatitis C virus infection only (2.2 vs 10.8 MEq/ml, p=0.02). Only 3 hepatitis G virus carriers had persistently elevated alanine aminotransferase compared to 29 hepatitis C virus carriers (14% vs 60%, p
AB - Background. Prevalence and pathogenicity of hepatitis G virus infection in long-term renal transplant recipients, are not fully known. Aim. To evaluate long-term impact of HGV infection on liver disease of renal transplanted patients. Patients and Methods. A total of 155 hepatitis B surface antigen negative kidney transplant recipients, followed for a mean of 11 years after renal transplantation, were studied. Of these 48 (31%) patients had persistently elevated serum aminotransferase values. Frozen serum samples were tested for HGV-RNA and HCV-RNA by nested reverse transcribed polymerase chain reaction, and for anti-hepatitis G virus and anti-hepatitis C virus by enzyme-linked immunosorbent assay. Hepatitis C virus-RNA was typed by a line probe assay and quantified by a branched DNA signal amplification assay. Results. Hepatitis G virus-RNA was detected in 37 (24%) patients and anti-hepatitis G virus in another 26 (17%). Seventy (45%) patients had serum anti-hepatitis C virus and 63 of these (90%) had serum hepatitis C virus-RNA. Hepatitis G virus-RNA positive and negative patients were similar in terms of age, sex, duration of dialysis, rate of transfusion, chronic liver disease, rate of hepatitis C virus infection and immunosuppressive therapy. Fifteen (41%) hepatitis G virus-RNA seropositive patients were hepatitis C virus co-infected. Hepatitis C virus-RNA levels were significantly lower in the 15 hepatitis C virus/hepatitis G virus co-infected patients than in the 48 patients with hepatitis C virus infection only (2.2 vs 10.8 MEq/ml, p=0.02). Only 3 hepatitis G virus carriers had persistently elevated alanine aminotransferase compared to 29 hepatitis C virus carriers (14% vs 60%, p
KW - Hepatitis C virus
KW - Hepatitis G virus
KW - Kidney transplantation
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M3 - Article
C2 - 11572574
AN - SCOPUS:0034851848
VL - 33
SP - 477
EP - 479
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 6
ER -