High prevalence, low pathogenicity of hepatitis G virus in kidney transplant recipients

F. De Filippi, P. Lampertico, R. Soffredini, M. G. Rumi, G. Lunghi, A. Aroldi, A. Tarantino, C. Ponticelli, M. Colombo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background. Prevalence and pathogenicity of hepatitis G virus infection in long-term renal transplant recipients, are not fully known. Aim. To evaluate long-term impact of HGV infection on liver disease of renal transplanted patients. Patients and Methods. A total of 155 hepatitis B surface antigen negative kidney transplant recipients, followed for a mean of 11 years after renal transplantation, were studied. Of these 48 (31%) patients had persistently elevated serum aminotransferase values. Frozen serum samples were tested for HGV-RNA and HCV-RNA by nested reverse transcribed polymerase chain reaction, and for anti-hepatitis G virus and anti-hepatitis C virus by enzyme-linked immunosorbent assay. Hepatitis C virus-RNA was typed by a line probe assay and quantified by a branched DNA signal amplification assay. Results. Hepatitis G virus-RNA was detected in 37 (24%) patients and anti-hepatitis G virus in another 26 (17%). Seventy (45%) patients had serum anti-hepatitis C virus and 63 of these (90%) had serum hepatitis C virus-RNA. Hepatitis G virus-RNA positive and negative patients were similar in terms of age, sex, duration of dialysis, rate of transfusion, chronic liver disease, rate of hepatitis C virus infection and immunosuppressive therapy. Fifteen (41%) hepatitis G virus-RNA seropositive patients were hepatitis C virus co-infected. Hepatitis C virus-RNA levels were significantly lower in the 15 hepatitis C virus/hepatitis G virus co-infected patients than in the 48 patients with hepatitis C virus infection only (2.2 vs 10.8 MEq/ml, p=0.02). Only 3 hepatitis G virus carriers had persistently elevated alanine aminotransferase compared to 29 hepatitis C virus carriers (14% vs 60%, p

Original languageEnglish
Pages (from-to)477-479
Number of pages3
JournalDigestive and Liver Disease
Volume33
Issue number6
Publication statusPublished - 2001

Fingerprint

GB virus C
Hepacivirus
Virulence
Kidney
RNA
Virus Diseases
Serum
Liver Diseases
Branched DNA Signal Amplification Assay
Transplant Recipients
Immunosuppressive Agents
Hepatitis B Surface Antigens
Transaminases
Alanine Transaminase
Kidney Transplantation
Dialysis
Chronic Disease
Enzyme-Linked Immunosorbent Assay

Keywords

  • Hepatitis C virus
  • Hepatitis G virus
  • Kidney transplantation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

High prevalence, low pathogenicity of hepatitis G virus in kidney transplant recipients. / De Filippi, F.; Lampertico, P.; Soffredini, R.; Rumi, M. G.; Lunghi, G.; Aroldi, A.; Tarantino, A.; Ponticelli, C.; Colombo, M.

In: Digestive and Liver Disease, Vol. 33, No. 6, 2001, p. 477-479.

Research output: Contribution to journalArticle

De Filippi, F. ; Lampertico, P. ; Soffredini, R. ; Rumi, M. G. ; Lunghi, G. ; Aroldi, A. ; Tarantino, A. ; Ponticelli, C. ; Colombo, M. / High prevalence, low pathogenicity of hepatitis G virus in kidney transplant recipients. In: Digestive and Liver Disease. 2001 ; Vol. 33, No. 6. pp. 477-479.
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abstract = "Background. Prevalence and pathogenicity of hepatitis G virus infection in long-term renal transplant recipients, are not fully known. Aim. To evaluate long-term impact of HGV infection on liver disease of renal transplanted patients. Patients and Methods. A total of 155 hepatitis B surface antigen negative kidney transplant recipients, followed for a mean of 11 years after renal transplantation, were studied. Of these 48 (31{\%}) patients had persistently elevated serum aminotransferase values. Frozen serum samples were tested for HGV-RNA and HCV-RNA by nested reverse transcribed polymerase chain reaction, and for anti-hepatitis G virus and anti-hepatitis C virus by enzyme-linked immunosorbent assay. Hepatitis C virus-RNA was typed by a line probe assay and quantified by a branched DNA signal amplification assay. Results. Hepatitis G virus-RNA was detected in 37 (24{\%}) patients and anti-hepatitis G virus in another 26 (17{\%}). Seventy (45{\%}) patients had serum anti-hepatitis C virus and 63 of these (90{\%}) had serum hepatitis C virus-RNA. Hepatitis G virus-RNA positive and negative patients were similar in terms of age, sex, duration of dialysis, rate of transfusion, chronic liver disease, rate of hepatitis C virus infection and immunosuppressive therapy. Fifteen (41{\%}) hepatitis G virus-RNA seropositive patients were hepatitis C virus co-infected. Hepatitis C virus-RNA levels were significantly lower in the 15 hepatitis C virus/hepatitis G virus co-infected patients than in the 48 patients with hepatitis C virus infection only (2.2 vs 10.8 MEq/ml, p=0.02). Only 3 hepatitis G virus carriers had persistently elevated alanine aminotransferase compared to 29 hepatitis C virus carriers (14{\%} vs 60{\%}, p",
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AU - De Filippi, F.

AU - Lampertico, P.

AU - Soffredini, R.

AU - Rumi, M. G.

AU - Lunghi, G.

AU - Aroldi, A.

AU - Tarantino, A.

AU - Ponticelli, C.

AU - Colombo, M.

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