High prevalence of adenomas and microadenomas of the duodenal papilla and periampullary region in patients with familial adenomatous polyposis

Giorgio Bertoni, Romano Sassatelli, Evandro Nigrisoli, Marco Pennazio, Paolo Tansini, Arrigo Arrigoni, Maurizio Ponz De Leon, Francesco P. Rossini, Giuliano Bedogni

Research output: Contribution to journalArticle

Abstract

Background: Patients with familiar adenomatous polyposis (FAP) are traditionally considered to be at high risk for duodenal-papillary and periampullary adenomas and cancer. Aim: To evaluate prospectively the prevalence, histology and clinical significance of ampullary and periampullary macroscopic and microscopic lesions in our population of affected patients. Setting: Three gastroenterological departments of northern Italian hospitals. Patient and methods: Twenty-five affected patients were carefully investigated over a 24-month period by end-viewing and side-viewing upper panendoscopy. Biopsies were performed on representative macroscopic lesions and randomly on normal-appearing papillary and periampullary mucosa. Results: Seven patients had macroscopic adenomas of the duodenal papilla, three of the periampullary region and five at both sites (cumulative prevalence 40%). An additional six patients had macroadenomas in the rest of the duodenum (overall prevalence 64%). Microscopic adenomas were identified in nine and two patients in the papilla and periampullary region, respectively, and in three at both sites (overall prevalence 44%). Thus, a total of 17 (68%) patients presented macro- or microadenomas at these locations. The prevalence rose to 72%, when a further patient with macroadenomas in the rest of the duodenum only was included. Malignancy was not encountered and severe dysplasia was observed only in a macroadenoma of the second duodenal portion. A higher frequency of macroadenomas in the papilla and periampullary region was significantly correlated with the presence and number of such lesions in the rest of the duodenum (P = 0.04). No other significant association was detected either between micro- or macroadenomas at different sites or with the demographic, clinical and pathological features. Conclusion: This study confirms that the duodenal papilla and periampullary region are sites with high prevalence of macro- and microscopic adenomas in patients with FAP. However, our data do not seem to support a higher frequency and malignancy potential of such lesions as compared to polyps in the rest of the duodenum. Nevertheless, these findings warrant a periodic, careful examination of the duodenum with either end-viewing or side-viewing endoscopy, the need for random biopsies of the papilla and periampullary region and the removal of any larger or rapidly growing lesions detected.

Original languageEnglish
Pages (from-to)1201-1206
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Volume8
Issue number12
Publication statusPublished - 1996

Fingerprint

Adenomatous Polyposis Coli
Adenoma
Duodenum
Biopsy
Neoplasms
Polyps
Endoscopy
Histology
Mucous Membrane
Demography

Keywords

  • Adenomas
  • Duodenal polyps
  • Familial adenomatous polyposis
  • Microadenomas
  • Papillary polyps
  • Upper gastrointestinal endoscopy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

High prevalence of adenomas and microadenomas of the duodenal papilla and periampullary region in patients with familial adenomatous polyposis. / Bertoni, Giorgio; Sassatelli, Romano; Nigrisoli, Evandro; Pennazio, Marco; Tansini, Paolo; Arrigoni, Arrigo; Ponz De Leon, Maurizio; Rossini, Francesco P.; Bedogni, Giuliano.

In: European Journal of Gastroenterology and Hepatology, Vol. 8, No. 12, 1996, p. 1201-1206.

Research output: Contribution to journalArticle

Bertoni, G, Sassatelli, R, Nigrisoli, E, Pennazio, M, Tansini, P, Arrigoni, A, Ponz De Leon, M, Rossini, FP & Bedogni, G 1996, 'High prevalence of adenomas and microadenomas of the duodenal papilla and periampullary region in patients with familial adenomatous polyposis', European Journal of Gastroenterology and Hepatology, vol. 8, no. 12, pp. 1201-1206.
Bertoni, Giorgio ; Sassatelli, Romano ; Nigrisoli, Evandro ; Pennazio, Marco ; Tansini, Paolo ; Arrigoni, Arrigo ; Ponz De Leon, Maurizio ; Rossini, Francesco P. ; Bedogni, Giuliano. / High prevalence of adenomas and microadenomas of the duodenal papilla and periampullary region in patients with familial adenomatous polyposis. In: European Journal of Gastroenterology and Hepatology. 1996 ; Vol. 8, No. 12. pp. 1201-1206.
@article{69ce8a1e1349466895f7ec8b498c0851,
title = "High prevalence of adenomas and microadenomas of the duodenal papilla and periampullary region in patients with familial adenomatous polyposis",
abstract = "Background: Patients with familiar adenomatous polyposis (FAP) are traditionally considered to be at high risk for duodenal-papillary and periampullary adenomas and cancer. Aim: To evaluate prospectively the prevalence, histology and clinical significance of ampullary and periampullary macroscopic and microscopic lesions in our population of affected patients. Setting: Three gastroenterological departments of northern Italian hospitals. Patient and methods: Twenty-five affected patients were carefully investigated over a 24-month period by end-viewing and side-viewing upper panendoscopy. Biopsies were performed on representative macroscopic lesions and randomly on normal-appearing papillary and periampullary mucosa. Results: Seven patients had macroscopic adenomas of the duodenal papilla, three of the periampullary region and five at both sites (cumulative prevalence 40{\%}). An additional six patients had macroadenomas in the rest of the duodenum (overall prevalence 64{\%}). Microscopic adenomas were identified in nine and two patients in the papilla and periampullary region, respectively, and in three at both sites (overall prevalence 44{\%}). Thus, a total of 17 (68{\%}) patients presented macro- or microadenomas at these locations. The prevalence rose to 72{\%}, when a further patient with macroadenomas in the rest of the duodenum only was included. Malignancy was not encountered and severe dysplasia was observed only in a macroadenoma of the second duodenal portion. A higher frequency of macroadenomas in the papilla and periampullary region was significantly correlated with the presence and number of such lesions in the rest of the duodenum (P = 0.04). No other significant association was detected either between micro- or macroadenomas at different sites or with the demographic, clinical and pathological features. Conclusion: This study confirms that the duodenal papilla and periampullary region are sites with high prevalence of macro- and microscopic adenomas in patients with FAP. However, our data do not seem to support a higher frequency and malignancy potential of such lesions as compared to polyps in the rest of the duodenum. Nevertheless, these findings warrant a periodic, careful examination of the duodenum with either end-viewing or side-viewing endoscopy, the need for random biopsies of the papilla and periampullary region and the removal of any larger or rapidly growing lesions detected.",
keywords = "Adenomas, Duodenal polyps, Familial adenomatous polyposis, Microadenomas, Papillary polyps, Upper gastrointestinal endoscopy",
author = "Giorgio Bertoni and Romano Sassatelli and Evandro Nigrisoli and Marco Pennazio and Paolo Tansini and Arrigo Arrigoni and {Ponz De Leon}, Maurizio and Rossini, {Francesco P.} and Giuliano Bedogni",
year = "1996",
language = "English",
volume = "8",
pages = "1201--1206",
journal = "European Journal of Gastroenterology and Hepatology",
issn = "0954-691X",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - High prevalence of adenomas and microadenomas of the duodenal papilla and periampullary region in patients with familial adenomatous polyposis

AU - Bertoni, Giorgio

AU - Sassatelli, Romano

AU - Nigrisoli, Evandro

AU - Pennazio, Marco

AU - Tansini, Paolo

AU - Arrigoni, Arrigo

AU - Ponz De Leon, Maurizio

AU - Rossini, Francesco P.

AU - Bedogni, Giuliano

PY - 1996

Y1 - 1996

N2 - Background: Patients with familiar adenomatous polyposis (FAP) are traditionally considered to be at high risk for duodenal-papillary and periampullary adenomas and cancer. Aim: To evaluate prospectively the prevalence, histology and clinical significance of ampullary and periampullary macroscopic and microscopic lesions in our population of affected patients. Setting: Three gastroenterological departments of northern Italian hospitals. Patient and methods: Twenty-five affected patients were carefully investigated over a 24-month period by end-viewing and side-viewing upper panendoscopy. Biopsies were performed on representative macroscopic lesions and randomly on normal-appearing papillary and periampullary mucosa. Results: Seven patients had macroscopic adenomas of the duodenal papilla, three of the periampullary region and five at both sites (cumulative prevalence 40%). An additional six patients had macroadenomas in the rest of the duodenum (overall prevalence 64%). Microscopic adenomas were identified in nine and two patients in the papilla and periampullary region, respectively, and in three at both sites (overall prevalence 44%). Thus, a total of 17 (68%) patients presented macro- or microadenomas at these locations. The prevalence rose to 72%, when a further patient with macroadenomas in the rest of the duodenum only was included. Malignancy was not encountered and severe dysplasia was observed only in a macroadenoma of the second duodenal portion. A higher frequency of macroadenomas in the papilla and periampullary region was significantly correlated with the presence and number of such lesions in the rest of the duodenum (P = 0.04). No other significant association was detected either between micro- or macroadenomas at different sites or with the demographic, clinical and pathological features. Conclusion: This study confirms that the duodenal papilla and periampullary region are sites with high prevalence of macro- and microscopic adenomas in patients with FAP. However, our data do not seem to support a higher frequency and malignancy potential of such lesions as compared to polyps in the rest of the duodenum. Nevertheless, these findings warrant a periodic, careful examination of the duodenum with either end-viewing or side-viewing endoscopy, the need for random biopsies of the papilla and periampullary region and the removal of any larger or rapidly growing lesions detected.

AB - Background: Patients with familiar adenomatous polyposis (FAP) are traditionally considered to be at high risk for duodenal-papillary and periampullary adenomas and cancer. Aim: To evaluate prospectively the prevalence, histology and clinical significance of ampullary and periampullary macroscopic and microscopic lesions in our population of affected patients. Setting: Three gastroenterological departments of northern Italian hospitals. Patient and methods: Twenty-five affected patients were carefully investigated over a 24-month period by end-viewing and side-viewing upper panendoscopy. Biopsies were performed on representative macroscopic lesions and randomly on normal-appearing papillary and periampullary mucosa. Results: Seven patients had macroscopic adenomas of the duodenal papilla, three of the periampullary region and five at both sites (cumulative prevalence 40%). An additional six patients had macroadenomas in the rest of the duodenum (overall prevalence 64%). Microscopic adenomas were identified in nine and two patients in the papilla and periampullary region, respectively, and in three at both sites (overall prevalence 44%). Thus, a total of 17 (68%) patients presented macro- or microadenomas at these locations. The prevalence rose to 72%, when a further patient with macroadenomas in the rest of the duodenum only was included. Malignancy was not encountered and severe dysplasia was observed only in a macroadenoma of the second duodenal portion. A higher frequency of macroadenomas in the papilla and periampullary region was significantly correlated with the presence and number of such lesions in the rest of the duodenum (P = 0.04). No other significant association was detected either between micro- or macroadenomas at different sites or with the demographic, clinical and pathological features. Conclusion: This study confirms that the duodenal papilla and periampullary region are sites with high prevalence of macro- and microscopic adenomas in patients with FAP. However, our data do not seem to support a higher frequency and malignancy potential of such lesions as compared to polyps in the rest of the duodenum. Nevertheless, these findings warrant a periodic, careful examination of the duodenum with either end-viewing or side-viewing endoscopy, the need for random biopsies of the papilla and periampullary region and the removal of any larger or rapidly growing lesions detected.

KW - Adenomas

KW - Duodenal polyps

KW - Familial adenomatous polyposis

KW - Microadenomas

KW - Papillary polyps

KW - Upper gastrointestinal endoscopy

UR - http://www.scopus.com/inward/record.url?scp=0029850532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029850532&partnerID=8YFLogxK

M3 - Article

C2 - 8980941

AN - SCOPUS:0029850532

VL - 8

SP - 1201

EP - 1206

JO - European Journal of Gastroenterology and Hepatology

JF - European Journal of Gastroenterology and Hepatology

SN - 0954-691X

IS - 12

ER -