High prevalence of ALK+/ROS1+ cases in pulmonary adenocarcinoma of adoloscents and young adults

Stefania Scarpino, Gian Luca Rampioni Vinciguerra, Arianna Di Napoli, Flavio Fochetti, Stefania Uccini, Daniela Iacono, Paolo Marchetti, Luigi Ruco

Research output: Contribution to journalArticle

Abstract

Objectives: To investigate prevalence and age-distribution of ALK- or ROS1-translocated adenocarcinomas in patients ≤50 years of age. Materials and methods: Paraffin sections of pulmonary adenocarcinoma were analyzed for ALK (637 cases) and ROS1 (376 cases) translocations using FISH, and for EGFR mutations (789 cases) using mutant-specific Real-Time PCR. Results: ALK or ROS1 fusions were detected in 55 of 637 cases (8.6%). When patients were stratified for age, it was found that six of six cases (100%) of lung adenocarcinoma diagnosed in patients

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalLung Cancer
Volume97
DOIs
Publication statusPublished - Jul 1 2016

Keywords

  • Adenocarcinoma
  • ALK
  • Lung
  • Pediatric patients
  • Pulmonary
  • ROS1

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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  • Cite this

    Scarpino, S., Rampioni Vinciguerra, G. L., Di Napoli, A., Fochetti, F., Uccini, S., Iacono, D., Marchetti, P., & Ruco, L. (2016). High prevalence of ALK+/ROS1+ cases in pulmonary adenocarcinoma of adoloscents and young adults. Lung Cancer, 97, 95-98. https://doi.org/10.1016/j.lungcan.2016.04.022