High prevalence of antibodies to hepatitis C virus in hemodialysis units using a second generation assay

M. U. Mondelli, G. Cristina, V. Piazza, A. Cerino, G. Villa, A. Salvadeo

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the prevalence and significance of antibodies to hepatitis C virus (HCV) in patients and staff from 3 dialysis units, using a 2nd generation assay (2nd g.a.; Ortho HCV). Of 277 patients, 151 (55%) were positive by 2nd and 85 (31%) by 1st g.a. Significant associations with the anti-HCV carrier status were: blood transfusions, retrospective finding of elevated ALT and duration of dialysis treatment, independently of transfusions. Of the 74 staff members, 5 were positive by 2nd and 3 by 1st g.a. Our data suggest that the 2nd g.a. is more sensitive in detecting HCV exposure in dialysis units and that duration of dialysis is a significant factor in acquiring HCV infection.

Original languageEnglish
Pages (from-to)350-351
Number of pages2
JournalNephron
Volume61
Issue number3
Publication statusPublished - 1992

Keywords

  • Alanine aminotransferase
  • Anti-HCV
  • Hemodialysis
  • Hepatitis C virus
  • Non-A hepatitis
  • Non-B hepatitis

ASJC Scopus subject areas

  • Nephrology

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