High prevalence of BK Polyomavirus Sequences in Human Papillomavirus-16-Positive Precancerous Cervical Lesions

Manola Comar, Daniela Bonifacio, Fabrizio Zanconati, Michela Di Napoli, Erica Isidoro, Fernanda Martini, Lucio Torelli, Mauro Tognon

Research output: Contribution to journalArticle

Abstract

High- and low-grade cervical lesions were analyzed for the presence of polyomavirus (PYV) and human papillomavirus (HPV) sequences. In precancerous cervical lesions, the overall prevalence of PYV sequences was 44% (41/93). Specifically, among the PYV-positive samples, 83% (34/41) tested positive for BK polyomavirus (BKV) sequences, whereas 17% (7/41) were positive for JC-virus. None of the samples were positive for simian virus 40. The presence of BKV DNA in high-grade squamous intraepithelial lesions was confirmed by in situ PCR. BKV sequences were detected more frequently in high-grade squamous intraepithelial lesions, together with the genotype HPV-16. The association of BKV with precancerous cervical lesions suggests that this polyomavirus participates with HPV-16 in the cell transformation process. Alternatively, BKV might multiply better in HPV-16-positive cells from precancerous cervical lesions than in HPV-16-negative cells.

Original languageEnglish
Pages (from-to)1770-1776
Number of pages7
JournalJournal of Medical Virology
Volume83
Issue number10
DOIs
Publication statusPublished - Oct 2011

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Keywords

  • Cervical lesion
  • Human papillomavirus
  • Polyomavirus
  • Viral load

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Comar, M., Bonifacio, D., Zanconati, F., Di Napoli, M., Isidoro, E., Martini, F., Torelli, L., & Tognon, M. (2011). High prevalence of BK Polyomavirus Sequences in Human Papillomavirus-16-Positive Precancerous Cervical Lesions. Journal of Medical Virology, 83(10), 1770-1776. https://doi.org/10.1002/jmv.22184