High prevalence of chlamydophila psittaci subclinical infection in italian patients with sjögren's syndrome and parotid gland marginal zone B-cell lymphoma of MALT-type

Martina Fabris, Riccardo Dolcetti, Elisa Pasini, Luca Quartuccio, Elena Pontarini, Sara Salvin, Maurilio Ponzoni, Cathryn Anne Scott, Salvatore De Vita

Research output: Contribution to journalArticle

Abstract

Objective To assess Chlamydophila psittaci (Cp) subclinical infection in patients with Sjögren's syndrome (SS). Methods Seventy-four SS patients (55.4 ±13.4 yrs; 94.6% females) were studied. Among them, 18 had salivary gland mucosa- associated lymphoid tissue (MALT) B-cell lymphoma, 20 myoepithelial sialoadenitis (MESA), and 36 no lymphoproliferative disorders (LPD). The presence of Cp DNA was assessed in peripheral blood of all patients by specific PCR protocols. Paired salivary gland samples were also investigated whenever available (34 cases), including lymphomatous and non-lymphomatous samples, as well as major and minor salivary gland tissues. As controls, 225 blood donors were analysed in the peripheral blood. Results Overall, Cp DNA was detected in 11/74 (14.9%) SS patients vs. 1/225 (0.4%) controls (p

Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalClinical and Experimental Rheumatology
Volume32
Issue number1
Publication statusPublished - 2014

Keywords

  • Chlamydophila psittaci
  • Infection
  • Lymphomagenesis
  • MALT lymphoma
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

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