Elevata frequenza della infezione da virus dell'epatite C nei pazienti con linfoma non-Hodgkin all'esordio. Risultati preliminari di uno studio multicentrico italiano

Translated title of the contribution: High prevalence of hepatitis C virus (HCV) infection in patients with non-Hodgkin lymphoma at the onset. Preliminary results of a Multicentre Italian Study

Carlo Catassi, Elisabetta Fabiani, Giovanni V. Coppa, Armando Gabrielli, Riccardo Centurioni, Pietro Leoni, Maria Barbato, Franca Viola, Maurizio Martelli, Amalia De Renzo, Bruno Rotoli, Paolo Bertolani, Massimo Federico, Antonio Carroccio, Emilio Iannitto, Mariella Baldassarre, Attilio Guarini, Graziella Guariso, Giovanni Favaretto, Paola CaramaschiAchille Ambrosetti

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

143 patients with non-Hodgkin lymphoma (NHL) at the onset entered this perspective study on NHL-associated risk factors. They were 87 males and 56 females with a mean age of 52.3 years (range 14.6-82.3). An associated hepatitis C virus (HCV) infection was found in 16 of the 143 NHL cases (11.2%; 95% CI 6.5-17.5). They were 11 males and 5 females [mean age 59.9] year with disseminated (13/16) or localized NHL disease (3/16)]. The NHL histological subgroup was low grade (6/16), intermediate grade (2/16) or high grade (8/16). The cell origin was B in 15/16 cases and B cell-T cell rich in 1/16. The discovery of HCV infection was contemporary to lymphoma diagnosis in 6/16 cases but preceded the NHL onset in the other 10 patients. In these 10 patients the median time between HCV infection diagnosis and NHL onset was 3.6 years (range 1-14.5). These data confirm that in Italy the prevalence of HCV infection in patients with NHL (11.2%) is significantly higher than expected in the general population (1.3-3.2%). The finding that, in most cases, HCV infection was definitely antecedent to NHL onset, usually by years, adds evidence to the possible causative role of the HCV in lymphomagenesis.

Original languageItalian
Pages (from-to)63-67
Number of pages5
JournalRecenti Progressi in Medicina
Volume89
Issue number2
Publication statusPublished - Feb 1998

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Virus Diseases
Hepacivirus
Non-Hodgkin's Lymphoma
Multicenter Studies
Satellite Viruses
Italy
Lymphoma
B-Lymphocytes
T-Lymphocytes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Elevata frequenza della infezione da virus dell'epatite C nei pazienti con linfoma non-Hodgkin all'esordio. Risultati preliminari di uno studio multicentrico italiano. / Catassi, Carlo; Fabiani, Elisabetta; Coppa, Giovanni V.; Gabrielli, Armando; Centurioni, Riccardo; Leoni, Pietro; Barbato, Maria; Viola, Franca; Martelli, Maurizio; De Renzo, Amalia; Rotoli, Bruno; Bertolani, Paolo; Federico, Massimo; Carroccio, Antonio; Iannitto, Emilio; Baldassarre, Mariella; Guarini, Attilio; Guariso, Graziella; Favaretto, Giovanni; Caramaschi, Paola; Ambrosetti, Achille.

In: Recenti Progressi in Medicina, Vol. 89, No. 2, 02.1998, p. 63-67.

Research output: Contribution to journalArticle

Catassi, C, Fabiani, E, Coppa, GV, Gabrielli, A, Centurioni, R, Leoni, P, Barbato, M, Viola, F, Martelli, M, De Renzo, A, Rotoli, B, Bertolani, P, Federico, M, Carroccio, A, Iannitto, E, Baldassarre, M, Guarini, A, Guariso, G, Favaretto, G, Caramaschi, P & Ambrosetti, A 1998, 'Elevata frequenza della infezione da virus dell'epatite C nei pazienti con linfoma non-Hodgkin all'esordio. Risultati preliminari di uno studio multicentrico italiano', Recenti Progressi in Medicina, vol. 89, no. 2, pp. 63-67.
Catassi, Carlo ; Fabiani, Elisabetta ; Coppa, Giovanni V. ; Gabrielli, Armando ; Centurioni, Riccardo ; Leoni, Pietro ; Barbato, Maria ; Viola, Franca ; Martelli, Maurizio ; De Renzo, Amalia ; Rotoli, Bruno ; Bertolani, Paolo ; Federico, Massimo ; Carroccio, Antonio ; Iannitto, Emilio ; Baldassarre, Mariella ; Guarini, Attilio ; Guariso, Graziella ; Favaretto, Giovanni ; Caramaschi, Paola ; Ambrosetti, Achille. / Elevata frequenza della infezione da virus dell'epatite C nei pazienti con linfoma non-Hodgkin all'esordio. Risultati preliminari di uno studio multicentrico italiano. In: Recenti Progressi in Medicina. 1998 ; Vol. 89, No. 2. pp. 63-67.
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AU - Fabiani, Elisabetta

AU - Coppa, Giovanni V.

AU - Gabrielli, Armando

AU - Centurioni, Riccardo

AU - Leoni, Pietro

AU - Barbato, Maria

AU - Viola, Franca

AU - Martelli, Maurizio

AU - De Renzo, Amalia

AU - Rotoli, Bruno

AU - Bertolani, Paolo

AU - Federico, Massimo

AU - Carroccio, Antonio

AU - Iannitto, Emilio

AU - Baldassarre, Mariella

AU - Guarini, Attilio

AU - Guariso, Graziella

AU - Favaretto, Giovanni

AU - Caramaschi, Paola

AU - Ambrosetti, Achille

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