High prevalence of hepatitis G virus infection in Hodgkin's disease and B-cell lymphoproliferative disorders: Absence of correlation with hepatitis C virus infection

Amalia De Renzo; Eliana Persico; Fedele De Marino; Giovanni Di Giacomo Russo; Rosario Notaro; Carmen Di Grazia; Marco Picardi; Lidia Santoro; Roberto Torella; Bruno Rotoli; Marcello Persico

High prevalence of hepatitis G virus infection in Hodgkin's disease and B-cell lymphoproliferative disorders: Absence of correlation with hepatitis C virus infection

Amalia De Renzo, Eliana Persico, Fedele De Marino, Giovanni Di Giacomo Russo, Rosario Notaro, Carmen Di Grazia, Marco Picardi, Lidia Santoro, Roberto Torella, Bruno Rotoli, Marcello Persico

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Objectives. During the last decade an epidemiological association between hepatitis C virus (HCV) and B-cell lymphoproliferative disorders (B-LPD) has been reported; the same association has not been observed for Hodgkin's disease (HD). Hepatitis G virus (HGV) shares genetic and biological features with HCV, thus it might also be involved in lymphomagenesis. Design and Methods. The aim of this study was to compare the prevalence of HCV and HGV infection in patients at diagnosis of B-LPD or HD. Results. We tested 227 consecutive untransfused patients (127 with B-LPD and 100 with HD) and 110 healthy controls. The prevalence of HCV infection was significantly higher in B-LPD patients than in controls (17.3% vs. 1.8%, p

Original language	English
Pages (from-to)	714-718
Number of pages	5
Journal	Haematologica
Volume	87
Issue number	7
Publication status	Published - 2002

Keywords

Epidemiology
Hepatitis C virus
Hepatitis G virus
Hodgkin's disease
Lymphoma
Lymphoproliferative disorders
Non-Hodgkin's lymphoma

ASJC Scopus subject areas

Hematology

Cite this

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title = "High prevalence of hepatitis G virus infection in Hodgkin's disease and B-cell lymphoproliferative disorders: Absence of correlation with hepatitis C virus infection",

abstract = "Background and Objectives. During the last decade an epidemiological association between hepatitis C virus (HCV) and B-cell lymphoproliferative disorders (B-LPD) has been reported; the same association has not been observed for Hodgkin's disease (HD). Hepatitis G virus (HGV) shares genetic and biological features with HCV, thus it might also be involved in lymphomagenesis. Design and Methods. The aim of this study was to compare the prevalence of HCV and HGV infection in patients at diagnosis of B-LPD or HD. Results. We tested 227 consecutive untransfused patients (127 with B-LPD and 100 with HD) and 110 healthy controls. The prevalence of HCV infection was significantly higher in B-LPD patients than in controls (17.3% vs. 1.8%, p",

keywords = "Epidemiology, Hepatitis C virus, Hepatitis G virus, Hodgkin's disease, Lymphoma, Lymphoproliferative disorders, Non-Hodgkin's lymphoma",

author = "{De Renzo}, Amalia and Eliana Persico and {De Marino}, Fedele and {Di Giacomo Russo}, Giovanni and Rosario Notaro and {Di Grazia}, Carmen and Marco Picardi and Lidia Santoro and Roberto Torella and Bruno Rotoli and Marcello Persico",

year = "2002",

language = "English",

volume = "87",

pages = "714--718",

journal = "Haematologica",

issn = "0390-6078",

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number = "7",

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TY - JOUR

T1 - High prevalence of hepatitis G virus infection in Hodgkin's disease and B-cell lymphoproliferative disorders

T2 - Absence of correlation with hepatitis C virus infection

AU - De Renzo, Amalia

AU - Persico, Eliana

AU - De Marino, Fedele

AU - Di Giacomo Russo, Giovanni

AU - Notaro, Rosario

AU - Di Grazia, Carmen

AU - Picardi, Marco

AU - Santoro, Lidia

AU - Torella, Roberto

AU - Rotoli, Bruno

AU - Persico, Marcello

PY - 2002

Y1 - 2002

N2 - Background and Objectives. During the last decade an epidemiological association between hepatitis C virus (HCV) and B-cell lymphoproliferative disorders (B-LPD) has been reported; the same association has not been observed for Hodgkin's disease (HD). Hepatitis G virus (HGV) shares genetic and biological features with HCV, thus it might also be involved in lymphomagenesis. Design and Methods. The aim of this study was to compare the prevalence of HCV and HGV infection in patients at diagnosis of B-LPD or HD. Results. We tested 227 consecutive untransfused patients (127 with B-LPD and 100 with HD) and 110 healthy controls. The prevalence of HCV infection was significantly higher in B-LPD patients than in controls (17.3% vs. 1.8%, p

AB - Background and Objectives. During the last decade an epidemiological association between hepatitis C virus (HCV) and B-cell lymphoproliferative disorders (B-LPD) has been reported; the same association has not been observed for Hodgkin's disease (HD). Hepatitis G virus (HGV) shares genetic and biological features with HCV, thus it might also be involved in lymphomagenesis. Design and Methods. The aim of this study was to compare the prevalence of HCV and HGV infection in patients at diagnosis of B-LPD or HD. Results. We tested 227 consecutive untransfused patients (127 with B-LPD and 100 with HD) and 110 healthy controls. The prevalence of HCV infection was significantly higher in B-LPD patients than in controls (17.3% vs. 1.8%, p

KW - Epidemiology

KW - Hepatitis C virus

KW - Hepatitis G virus

KW - Hodgkin's disease

KW - Lymphoma

KW - Lymphoproliferative disorders

KW - Non-Hodgkin's lymphoma

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M3 - Article

C2 - 12091122

AN - SCOPUS:0036075856

VL - 87

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EP - 718

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 7

ER -

High prevalence of hepatitis G virus infection in Hodgkin's disease and B-cell lymphoproliferative disorders: Absence of correlation with hepatitis C virus infection

Abstract

Keywords

ASJC Scopus subject areas

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