High prevalence of hepatitis G virus infection in Hodgkin's disease and B-cell lymphoproliferative disorders: Absence of correlation with hepatitis C virus infection

Amalia De Renzo, Eliana Persico, Fedele De Marino, Giovanni Di Giacomo Russo, Rosario Notaro, Carmen Di Grazia, Marco Picardi, Lidia Santoro, Roberto Torella, Bruno Rotoli, Marcello Persico

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objectives. During the last decade an epidemiological association between hepatitis C virus (HCV) and B-cell lymphoproliferative disorders (B-LPD) has been reported; the same association has not been observed for Hodgkin's disease (HD). Hepatitis G virus (HGV) shares genetic and biological features with HCV, thus it might also be involved in lymphomagenesis. Design and Methods. The aim of this study was to compare the prevalence of HCV and HGV infection in patients at diagnosis of B-LPD or HD. Results. We tested 227 consecutive untransfused patients (127 with B-LPD and 100 with HD) and 110 healthy controls. The prevalence of HCV infection was significantly higher in B-LPD patients than in controls (17.3% vs. 1.8%, p

Original languageEnglish
Pages (from-to)714-718
Number of pages5
JournalHaematologica
Volume87
Issue number7
Publication statusPublished - 2002

Keywords

  • Epidemiology
  • Hepatitis C virus
  • Hepatitis G virus
  • Hodgkin's disease
  • Lymphoma
  • Lymphoproliferative disorders
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Hematology

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