High prevalence of nonalcoholic fatty liver in patients with idiopathic venous thromboembolism

Matteo Nicola Dario Di Minno, Antonella Tufano, Anna Rusolillo, Giovanni Di Minno, Giovanni Tarantino

Research output: Contribution to journalArticlepeer-review


Aim: To assess the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with idiopathic venous thromboembolism (VTE). Methods: In a case-control study, after excluding subjects with well-consolidated risk factors for VTE, idiopathic VTE was documented in 138 consecutive patients who were referred to our department. Two hundred and seventy-six healthy sex/age/body-massindex- matched subjects, without any clinical/instrumental evidence of VTE, served as controls. All underwent a clinical/laboratory/ultrasound assessment for the presence of metabolic syndrome and NAFLD. Results: NAFLD was detected in 112/138 cases (81%) and in 84/276 controls (30%) [risk ratio: 2.7, 95% confidence interval (CI): 2.2-3.2, P <0.0001]. Metabolic syndrome and smoking habit were more prevalent in patients with idiopathic VTE. The high prevalence of NAFLD in VTE was also confirmed after adjustment for inherited thrombophilia. NAFLD was clearly predicted by VTE (odds ratio: 1.8, 95% CI: 1.2-2.7, P <0.0001). Conclusion: NAFLD was independently associated with idiopathic VTE.

Original languageEnglish
Pages (from-to)6119-6122
Number of pages4
JournalWorld Journal of Gastroenterology
Issue number48
Publication statusPublished - Dec 2010


  • Metabolic syndrome
  • Nonalcoholic fatty liver disease
  • Thromboembolism

ASJC Scopus subject areas

  • Gastroenterology


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