High prevalence of prolonged qt interval duration in male patients with Cushing's disease

F. Pecori Giraldi, P. M. Toja, G. Michailidis, A. Metinidou, M. De Martin, M. Scacchi, M. Stramba-Badiale, F. Cavagnini

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Hypogonadal males have recently been shown to present prolonged QT interval, an electrocardiographic measure indicative of risk for fatal cardiac arrhythmias. Excess cortisol secretion induces low testosterone levels in male patients with Cushing's disease but no study has yet evaluated if this is accompanied by changes in QT interval duration. We therefore decided to evaluate whether male patients with Cushing's disease present changes in QT interval duration. QT interval was measured in electrocardiographic readings from 19 men and 35 women with Cushing's disease and age- and sex-matched controls were used for comparison. QT interval was corrected for heart rate according to Bazett's formula (QTc) and QTc >440 msec and >460 msec were taken as indicative of increased risk for torsade de pointes in men and women, respectively. Mean QTc was significantly longer in male patients compared with healthy controls (426.9±9.27 vs. 389.7±8.31, p

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalExperimental and Clinical Endocrinology and Diabetes
Issue number4
Publication statusPublished - 2011



  • cardiac arrhythmia
  • Cushing's syndrome
  • hypogonadism
  • QT interval

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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