High prevalence of prolonged qt interval in obese hypogonadal males

Francesca Pecori Giraldi; Giuseppina Manzoni; Jorgo Michailidis; Massimo Scacchi; Marco Stramba-Badiale; Francesco Cavagnini

doi:10.1038/oby.2011.33

High prevalence of prolonged qt interval in obese hypogonadal males

Francesca Pecori Giraldi, Giuseppina Manzoni, Jorgo Michailidis, Massimo Scacchi, Marco Stramba-Badiale, Francesco Cavagnini

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Obese subjects show several electrocardiographic alterations, including prolonged QT interval, a marker for fatal cardiac arrhythmias. Prolonged QT interval has recently been linked to low testosterone levels, a frequent occurrence in male obese patients but no study has yet assessed whether hypoandrogenism contributes to QT interval prolongation in this population. Aim of this study was to evaluate whether prolonged QT interval is linked to hypogonadism in male obese subjects. QT interval corrected for heart rate (QTc) was measured from standard electrocardiogram recordings in 136 obese men (BMI 30 kg/m ², range 30.1-75.4kg/m ²). Obese men were classified as eugonadal or hypogonadal according to serum total testosterone levels (i.e., greater or less than 9.9nmol/l). Our study showed that QTc measurements corrected by either Bazett (419±3.2 vs. 408±3.4ms, P

Original language	English
Pages (from-to)	2015-2018
Number of pages	4
Journal	Obesity
Volume	19
Issue number	10
DOIs	https://doi.org/10.1038/oby.2011.33
Publication status	Published - Oct 2011

ASJC Scopus subject areas

Endocrinology
Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

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AU - Michailidis, Jorgo

AU - Scacchi, Massimo

AU - Stramba-Badiale, Marco

AU - Cavagnini, Francesco

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