High prevalence of risk factors for cardiovascular disease in parents of IDDM patients with albuminuria

S. De Cosmo, S. Bacci, G. P. Piras, M. Cignarelli, G. Placentino, M. Margaglione, D. Colaizzo, G. Di Minno, R. Giorgino, A. Liuzzi, G. C. Viberti

Research output: Contribution to journalArticlepeer-review

Abstract

Life expectancy is shorter in the subset of insulin-dependent diabetic (IDDM) patients who are susceptible to kidney disease. Familial factors may be important. In this study the prevalence of cardiovascular disease mortality and morbidity and of risk factors for cardiovascular disease was compared in the parents of 31 IDDM patients with elevated albumin excretion rate (AER > 45 μg/min; group A) with that of parents of 31 insulin-dependent diabetic patients with normoalbuminuria (AER <20 μg/min; group B). The two diabetic patient groups were matched for age and duration of disease. Information on deceased parents was obtained from death certificates and clinical records and morbidity for cardiovascular disease was ascertained using the World Health Organization questionnaire and Minnesota coded ECG. Hyperlipidaemia was defined as serum cholesterol higher than 6 mmol/l and/or plasma triglycerides higher than 2.3 mmol/l and/or lipid lowering therapy; arterial hypertension as systolic blood pressure higher than 140 mmHg and/or diastolic blood pressure higher than 90 mmHg and/or antihypertensive treatment. The percentage of dead parents was similar in the two groups (26 vs 20% for parents of group A vs group B, respectively), but the parents of the diabetic patients with elevated AER had died at a younger age (58±10 vs 70±14 years; p

Original languageEnglish
Pages (from-to)1191-1196
Number of pages6
JournalDiabetologia
Volume40
Issue number10
DOIs
Publication statusPublished - 1997

Keywords

  • Cardiovascular disease
  • Hyperlipidaemia
  • Insulin resistance
  • Insulin-dependent diabetes mellitus
  • Proteinuria

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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