High prevalence of T-cell receptor Vδ2-(D)-Dδ3 or Dδ1/2-Dδ3 rearrangements in B-precursor acute lymphoblastic leukemias

Andrea Biondi, Paola Francia Di Celle, Vincenzo Rossi, Giulia Casorati, Giuseppe Matullo, Giovanni Giudici, Robin Foa, Nicola Migone

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Abstract

Rearrangement of the immunoglobulin (Ig) and T-cell receptor (TcR) genes generally has been considered a useful marker of B- and T-cell lineage in lymphoproliferative disorders. However, concomitant rearrangements of Ig and TcR genes have been commonly reported in the most immature lymphoid malignancies, mainly in B-cell precursor acute lymphoblastic leukemia (ALL). To better characterize the nature of this lineage promiscuity, we have analyzed the configuration of the TcR δ locus in 75 B-precursor ALL. The large majority of cases (87%) displayed a rearrangement or deletion at the δ locus. Among the 57 nondeletional rearrangements, two patterns were predominant and both appeared to derive from partial joining: a Vδ-(D)-Dδ3 (32/57) and a Dδ1/2-Dδ3 (11/57) type. A single V δ gene (Vδ2) appeared to be involved in the first type of rearrangement. These findings are at variance with T-ALL, where rearrangements 5′ to Vδ2 are usually found. It remains to be elucidated whether this incomplete attempt of Vδ2 gene assembly is related to the neoplastic event or represents a physiologic predisposition occurring during early stages of the normal lymphocyte differentiation.

Original languageEnglish
Pages (from-to)1834-1840
Number of pages7
JournalBlood
Volume75
Issue number9
Publication statusPublished - May 1 1990

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T-Cell Antigen Receptor
Precursor Cell Lymphoblastic Leukemia-Lymphoma
T-Cell Receptor Genes
Genes
Immunoglobulins
B-Lymphoid Precursor Cells
Lymphoproliferative Disorders
Cell Lineage
T-cells
Lymphocytes
Joining
T-Lymphocytes
Cells
Neoplasms

ASJC Scopus subject areas

  • Hematology

Cite this

High prevalence of T-cell receptor Vδ2-(D)-Dδ3 or Dδ1/2-Dδ3 rearrangements in B-precursor acute lymphoblastic leukemias. / Biondi, Andrea; Di Celle, Paola Francia; Rossi, Vincenzo; Casorati, Giulia; Matullo, Giuseppe; Giudici, Giovanni; Foa, Robin; Migone, Nicola.

In: Blood, Vol. 75, No. 9, 01.05.1990, p. 1834-1840.

Research output: Contribution to journalArticle

Biondi, A, Di Celle, PF, Rossi, V, Casorati, G, Matullo, G, Giudici, G, Foa, R & Migone, N 1990, 'High prevalence of T-cell receptor Vδ2-(D)-Dδ3 or Dδ1/2-Dδ3 rearrangements in B-precursor acute lymphoblastic leukemias', Blood, vol. 75, no. 9, pp. 1834-1840.
Biondi, Andrea ; Di Celle, Paola Francia ; Rossi, Vincenzo ; Casorati, Giulia ; Matullo, Giuseppe ; Giudici, Giovanni ; Foa, Robin ; Migone, Nicola. / High prevalence of T-cell receptor Vδ2-(D)-Dδ3 or Dδ1/2-Dδ3 rearrangements in B-precursor acute lymphoblastic leukemias. In: Blood. 1990 ; Vol. 75, No. 9. pp. 1834-1840.
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