High prevalence of T-cell receptor Vδ2-(D)-Dδ3 or Dδ1/2-Dδ3 rearrangements in B-precursor acute lymphoblastic leukemias

Andrea Biondi, Paola Francia Di Celle, Vincenzo Rossi, Giulia Casorati, Giuseppe Matullo, Giovanni Giudici, Robin Foa, Nicola Migone

Research output: Contribution to journalArticle

Abstract

Rearrangement of the immunoglobulin (Ig) and T-cell receptor (TcR) genes generally has been considered a useful marker of B- and T-cell lineage in lymphoproliferative disorders. However, concomitant rearrangements of Ig and TcR genes have been commonly reported in the most immature lymphoid malignancies, mainly in B-cell precursor acute lymphoblastic leukemia (ALL). To better characterize the nature of this lineage promiscuity, we have analyzed the configuration of the TcR δ locus in 75 B-precursor ALL. The large majority of cases (87%) displayed a rearrangement or deletion at the δ locus. Among the 57 nondeletional rearrangements, two patterns were predominant and both appeared to derive from partial joining: a Vδ-(D)-Dδ3 (32/57) and a Dδ1/2-Dδ3 (11/57) type. A single V δ gene (Vδ2) appeared to be involved in the first type of rearrangement. These findings are at variance with T-ALL, where rearrangements 5′ to Vδ2 are usually found. It remains to be elucidated whether this incomplete attempt of Vδ2 gene assembly is related to the neoplastic event or represents a physiologic predisposition occurring during early stages of the normal lymphocyte differentiation.

Original languageEnglish
Pages (from-to)1834-1840
Number of pages7
JournalBlood
Volume75
Issue number9
Publication statusPublished - May 1 1990

ASJC Scopus subject areas

  • Hematology

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    Biondi, A., Di Celle, P. F., Rossi, V., Casorati, G., Matullo, G., Giudici, G., Foa, R., & Migone, N. (1990). High prevalence of T-cell receptor Vδ2-(D)-Dδ3 or Dδ1/2-Dδ3 rearrangements in B-precursor acute lymphoblastic leukemias. Blood, 75(9), 1834-1840.