High prevalence of vertebral fractures assessed by quantitative morphometry in hemodialysis patients, strongly associated with vascular calcifications

Maria Fusaro, Giovanni Tripepi, Marianna Noale, Nicola Vajente, Mario Plebani, Martina Zaninotto, Giuseppe Guglielmi, Diego Miotto, Luca Dalle Carbonare, Angela D'Angelo, Daniele Ciurlino, Riccarda Puggia, Davide Miozzo, Sandro Giannini, Maurizio Gallieni

Research output: Contribution to journalArticle

Abstract

Few studies have provided information on the prevalence of vertebral fractures (VFs) and their risk factors in hemodialysis patients. A multicenter, cross-sectional, observational study was carried out to assess the prevalence of VFs and vascular calcifications (VCs) in 387 hemodialysis patients (mean age 64.2 ± 14.1 years, 63 % males) and in a control group of 51 osteoporotic subjects. Biochemical tests included 25(OH) vitamin D, bone Gla protein (total and undercarboxylated), and total matrix Gla protein. Vertebral quantitative morphometry was carried out centrally for the detection of VF, defined as reduction by ≥20 % of one of the vertebral body dimensions. In the same radiograph, aortic and iliac VC scores were calculated. Prevalence of VF was 55.3 % in hemodialysis patients and 51.0 % in the control group. Multivariate analysis disclosed that male gender (59.8 vs. 47.6 %, p = 0.02; OR = 1.78, 95 % CI 1.15-2.75) and age (mean ± SD 66.7 ± 13.1 vs. 61.0 ± 14.7 years, p <0.001; OR = 1.03, 95 % CI 1.01-1.05) were significantly associated with VF. The prevalence of aortic VC was significantly higher in hemodialysis patients than in controls (80.6 vs. 68.4 %, p = 0.001). The factors with the strongest association with VC, apart from atrial fibrillation, were serum 25(OH)vitamin D levels below 29 ng/mL for aortic VC (OR = 1.85, 95 % CI 1.04-3.29) and VF both for aortic (OR = 1.77, 95 % CI 1.00-3.14) and iliac (OR = 1.96, 95 % CI 1.27-3.04) VC. In conclusion, the prevalence of VF, especially in males, and VC, in both genders, is high in hemodialysis patients. VF is associated with VC. Vitamin D deficiency is also associated with VC. Further longitudinal studies are warranted to investigate fractures in renal patients.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalCalcified Tissue International
Volume93
Issue number1
DOIs
Publication statusPublished - Jul 2013

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Vascular Calcification
Renal Dialysis
Vitamin D
Control Groups
Vitamin D Deficiency
Osteocalcin
Atrial Fibrillation
Observational Studies
Longitudinal Studies
Multivariate Analysis
Cross-Sectional Studies
Kidney

Keywords

  • Hemodialysis
  • Prevalence
  • Vascular calcification
  • Vertebral fracture
  • Vitamin D

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

High prevalence of vertebral fractures assessed by quantitative morphometry in hemodialysis patients, strongly associated with vascular calcifications. / Fusaro, Maria; Tripepi, Giovanni; Noale, Marianna; Vajente, Nicola; Plebani, Mario; Zaninotto, Martina; Guglielmi, Giuseppe; Miotto, Diego; Carbonare, Luca Dalle; D'Angelo, Angela; Ciurlino, Daniele; Puggia, Riccarda; Miozzo, Davide; Giannini, Sandro; Gallieni, Maurizio.

In: Calcified Tissue International, Vol. 93, No. 1, 07.2013, p. 39-47.

Research output: Contribution to journalArticle

Fusaro, M, Tripepi, G, Noale, M, Vajente, N, Plebani, M, Zaninotto, M, Guglielmi, G, Miotto, D, Carbonare, LD, D'Angelo, A, Ciurlino, D, Puggia, R, Miozzo, D, Giannini, S & Gallieni, M 2013, 'High prevalence of vertebral fractures assessed by quantitative morphometry in hemodialysis patients, strongly associated with vascular calcifications', Calcified Tissue International, vol. 93, no. 1, pp. 39-47. https://doi.org/10.1007/s00223-013-9722-x
Fusaro, Maria ; Tripepi, Giovanni ; Noale, Marianna ; Vajente, Nicola ; Plebani, Mario ; Zaninotto, Martina ; Guglielmi, Giuseppe ; Miotto, Diego ; Carbonare, Luca Dalle ; D'Angelo, Angela ; Ciurlino, Daniele ; Puggia, Riccarda ; Miozzo, Davide ; Giannini, Sandro ; Gallieni, Maurizio. / High prevalence of vertebral fractures assessed by quantitative morphometry in hemodialysis patients, strongly associated with vascular calcifications. In: Calcified Tissue International. 2013 ; Vol. 93, No. 1. pp. 39-47.
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abstract = "Few studies have provided information on the prevalence of vertebral fractures (VFs) and their risk factors in hemodialysis patients. A multicenter, cross-sectional, observational study was carried out to assess the prevalence of VFs and vascular calcifications (VCs) in 387 hemodialysis patients (mean age 64.2 ± 14.1 years, 63 {\%} males) and in a control group of 51 osteoporotic subjects. Biochemical tests included 25(OH) vitamin D, bone Gla protein (total and undercarboxylated), and total matrix Gla protein. Vertebral quantitative morphometry was carried out centrally for the detection of VF, defined as reduction by ≥20 {\%} of one of the vertebral body dimensions. In the same radiograph, aortic and iliac VC scores were calculated. Prevalence of VF was 55.3 {\%} in hemodialysis patients and 51.0 {\%} in the control group. Multivariate analysis disclosed that male gender (59.8 vs. 47.6 {\%}, p = 0.02; OR = 1.78, 95 {\%} CI 1.15-2.75) and age (mean ± SD 66.7 ± 13.1 vs. 61.0 ± 14.7 years, p <0.001; OR = 1.03, 95 {\%} CI 1.01-1.05) were significantly associated with VF. The prevalence of aortic VC was significantly higher in hemodialysis patients than in controls (80.6 vs. 68.4 {\%}, p = 0.001). The factors with the strongest association with VC, apart from atrial fibrillation, were serum 25(OH)vitamin D levels below 29 ng/mL for aortic VC (OR = 1.85, 95 {\%} CI 1.04-3.29) and VF both for aortic (OR = 1.77, 95 {\%} CI 1.00-3.14) and iliac (OR = 1.96, 95 {\%} CI 1.27-3.04) VC. In conclusion, the prevalence of VF, especially in males, and VC, in both genders, is high in hemodialysis patients. VF is associated with VC. Vitamin D deficiency is also associated with VC. Further longitudinal studies are warranted to investigate fractures in renal patients.",
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AU - Fusaro, Maria

AU - Tripepi, Giovanni

AU - Noale, Marianna

AU - Vajente, Nicola

AU - Plebani, Mario

AU - Zaninotto, Martina

AU - Guglielmi, Giuseppe

AU - Miotto, Diego

AU - Carbonare, Luca Dalle

AU - D'Angelo, Angela

AU - Ciurlino, Daniele

AU - Puggia, Riccarda

AU - Miozzo, Davide

AU - Giannini, Sandro

AU - Gallieni, Maurizio

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N2 - Few studies have provided information on the prevalence of vertebral fractures (VFs) and their risk factors in hemodialysis patients. A multicenter, cross-sectional, observational study was carried out to assess the prevalence of VFs and vascular calcifications (VCs) in 387 hemodialysis patients (mean age 64.2 ± 14.1 years, 63 % males) and in a control group of 51 osteoporotic subjects. Biochemical tests included 25(OH) vitamin D, bone Gla protein (total and undercarboxylated), and total matrix Gla protein. Vertebral quantitative morphometry was carried out centrally for the detection of VF, defined as reduction by ≥20 % of one of the vertebral body dimensions. In the same radiograph, aortic and iliac VC scores were calculated. Prevalence of VF was 55.3 % in hemodialysis patients and 51.0 % in the control group. Multivariate analysis disclosed that male gender (59.8 vs. 47.6 %, p = 0.02; OR = 1.78, 95 % CI 1.15-2.75) and age (mean ± SD 66.7 ± 13.1 vs. 61.0 ± 14.7 years, p <0.001; OR = 1.03, 95 % CI 1.01-1.05) were significantly associated with VF. The prevalence of aortic VC was significantly higher in hemodialysis patients than in controls (80.6 vs. 68.4 %, p = 0.001). The factors with the strongest association with VC, apart from atrial fibrillation, were serum 25(OH)vitamin D levels below 29 ng/mL for aortic VC (OR = 1.85, 95 % CI 1.04-3.29) and VF both for aortic (OR = 1.77, 95 % CI 1.00-3.14) and iliac (OR = 1.96, 95 % CI 1.27-3.04) VC. In conclusion, the prevalence of VF, especially in males, and VC, in both genders, is high in hemodialysis patients. VF is associated with VC. Vitamin D deficiency is also associated with VC. Further longitudinal studies are warranted to investigate fractures in renal patients.

AB - Few studies have provided information on the prevalence of vertebral fractures (VFs) and their risk factors in hemodialysis patients. A multicenter, cross-sectional, observational study was carried out to assess the prevalence of VFs and vascular calcifications (VCs) in 387 hemodialysis patients (mean age 64.2 ± 14.1 years, 63 % males) and in a control group of 51 osteoporotic subjects. Biochemical tests included 25(OH) vitamin D, bone Gla protein (total and undercarboxylated), and total matrix Gla protein. Vertebral quantitative morphometry was carried out centrally for the detection of VF, defined as reduction by ≥20 % of one of the vertebral body dimensions. In the same radiograph, aortic and iliac VC scores were calculated. Prevalence of VF was 55.3 % in hemodialysis patients and 51.0 % in the control group. Multivariate analysis disclosed that male gender (59.8 vs. 47.6 %, p = 0.02; OR = 1.78, 95 % CI 1.15-2.75) and age (mean ± SD 66.7 ± 13.1 vs. 61.0 ± 14.7 years, p <0.001; OR = 1.03, 95 % CI 1.01-1.05) were significantly associated with VF. The prevalence of aortic VC was significantly higher in hemodialysis patients than in controls (80.6 vs. 68.4 %, p = 0.001). The factors with the strongest association with VC, apart from atrial fibrillation, were serum 25(OH)vitamin D levels below 29 ng/mL for aortic VC (OR = 1.85, 95 % CI 1.04-3.29) and VF both for aortic (OR = 1.77, 95 % CI 1.00-3.14) and iliac (OR = 1.96, 95 % CI 1.27-3.04) VC. In conclusion, the prevalence of VF, especially in males, and VC, in both genders, is high in hemodialysis patients. VF is associated with VC. Vitamin D deficiency is also associated with VC. Further longitudinal studies are warranted to investigate fractures in renal patients.

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