High prevalence of vitamin D deficiency in infertile women referring for assisted reproduction

Luca Pagliardini, Paola Viganó, Michela Molgora, Paola Persico, Andrea Salonia, Simona Helda Vailati, Alessio Paffoni, Edgardo Somigliana, Enrico Papaleo, Massimo Candiani

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A comprehensive analysis of the vitamin D status of infertile women is the first step in understanding hypovitaminosis impact on reproductive potential. We sought to determine vitamin D profiles of women attending an infertility center and to investigate non-dietary determinants of vitamin D status in this population. In this cross-sectional analysis, a cohort of 1072 women (mean age ± standard deviation 36.3 ± 4.4 years) attending an academic infertility center was used to examine serum 25-hydroxy-vitamin D (25(OH)D) levels in relation to demographic characteristics, seasons and general health risk factors. Both unadjusted and adjusted levels of serum 25(OH)D were examined. Median 25(OH)D concentration was below 30 ng/mL for 89% of the entire year. Over the whole year, 6.5% of patients had 25(OH)D levels ≤10 ng/mL, 40.1% ≤20 ng/mL, and 77.4% ≤30 ng/mL. Global solar radiation was weakly correlated with 25(OH)D levels. At multivariable analysis, 25(OH)D levels were inversely associated with BMI; conversely, 25(OH)D levels were positively associated with height and endometriosis history. Serum 25(OH)D levels are highly deficient in women seeking medical help for couple’s infertility. Levels are significantly associated with body composition, seasonal modifications and causes of infertility. Importantly, this deficiency status may last during pregnancy with more severe consequences.

Original languageEnglish
Pages (from-to)9972-9984
Number of pages13
JournalNutrients
Volume7
Issue number12
DOIs
Publication statusPublished - Dec 2 2015

Fingerprint

vitamin D deficiency
assisted reproductive technologies
Vitamin D Deficiency
vitamin D
Vitamin D
Infertility
Reproduction
Serum
vitamin deficiencies
Women's Rights
sociodemographic characteristics
Endometriosis
Body Composition
cross-sectional studies
body composition
solar radiation
risk factors
Cross-Sectional Studies
Demography
pregnancy

Keywords

  • 25(OH)D
  • Assisted reproduction
  • Endometriosis
  • Infertility
  • Vitamin D

ASJC Scopus subject areas

  • Food Science

Cite this

High prevalence of vitamin D deficiency in infertile women referring for assisted reproduction. / Pagliardini, Luca; Viganó, Paola; Molgora, Michela; Persico, Paola; Salonia, Andrea; Vailati, Simona Helda; Paffoni, Alessio; Somigliana, Edgardo; Papaleo, Enrico; Candiani, Massimo.

In: Nutrients, Vol. 7, No. 12, 02.12.2015, p. 9972-9984.

Research output: Contribution to journalArticle

Pagliardini, Luca ; Viganó, Paola ; Molgora, Michela ; Persico, Paola ; Salonia, Andrea ; Vailati, Simona Helda ; Paffoni, Alessio ; Somigliana, Edgardo ; Papaleo, Enrico ; Candiani, Massimo. / High prevalence of vitamin D deficiency in infertile women referring for assisted reproduction. In: Nutrients. 2015 ; Vol. 7, No. 12. pp. 9972-9984.
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