TY - JOUR
T1 - High rate of human herpesvirus-8 seroprevalence in thalassemic patients in Italy
AU - Cottoni, Francesca
AU - Santarelli, Roberta
AU - Gentile, Giuseppe
AU - Gallisai, Domenico
AU - Capobianchi, Angela
AU - Masala, Maria Vittoria
AU - Montesu, Maria Antonietta
AU - Coinu, Marisa
AU - Piras, Daniela
AU - Martino, Pietro
AU - Girelli, Gabriella
AU - Satta, Rosanna
AU - Cerimele, Decio
AU - Frati, Luigi
AU - Faggioni, Alberto
AU - Angeloni, Antonio
PY - 2004/5
Y1 - 2004/5
N2 - Background: The potential risk of acquiring infection by the novel human herpesvirus-8 (HHV-8) through blood derivatives is still debated. Objectives: In the present study, we determined HHV-8 seroprevalence in β-thalassemic patients living in Italy. Study design: We have analysed 86 patients from Sardinia, an island characterised by a high diffusion of HHV-8, as well as 33 thalassemics from the area of Rome, where a lower rate of HHV-8 infection has been reported. These data have been compared with HHV-8 seroprevalence found in healthy controls living in the same areas of the assayed patients. Results and conclusions: A three-fold increase in HHV-8 seroprevalence was found among thalassemic patients when compared to control groups taken from the same regions (17.6% versus 5.1%). This risk factor was statistically significant when considering the Sardinians alone (P=0.01) and the entire population analysed in the present survey (P=0.0006). In the Roman area also an increased seroprevalence in thalassemic subjects was found (12.1% versus 4.6%) but it was not statistically significant (P=0.2). HHV-8 is sporadically present in the blood of healthy individuals and it is unknown whether the virus eventually present in donors' blood is completely cleared by the treatments which blood undergoes before red cells are transfused. Based on these considerations, we hypothesise that multiply transfused subjects living in areas at high HHV-8 prevalence present an increased risk of being infected.
AB - Background: The potential risk of acquiring infection by the novel human herpesvirus-8 (HHV-8) through blood derivatives is still debated. Objectives: In the present study, we determined HHV-8 seroprevalence in β-thalassemic patients living in Italy. Study design: We have analysed 86 patients from Sardinia, an island characterised by a high diffusion of HHV-8, as well as 33 thalassemics from the area of Rome, where a lower rate of HHV-8 infection has been reported. These data have been compared with HHV-8 seroprevalence found in healthy controls living in the same areas of the assayed patients. Results and conclusions: A three-fold increase in HHV-8 seroprevalence was found among thalassemic patients when compared to control groups taken from the same regions (17.6% versus 5.1%). This risk factor was statistically significant when considering the Sardinians alone (P=0.01) and the entire population analysed in the present survey (P=0.0006). In the Roman area also an increased seroprevalence in thalassemic subjects was found (12.1% versus 4.6%) but it was not statistically significant (P=0.2). HHV-8 is sporadically present in the blood of healthy individuals and it is unknown whether the virus eventually present in donors' blood is completely cleared by the treatments which blood undergoes before red cells are transfused. Based on these considerations, we hypothesise that multiply transfused subjects living in areas at high HHV-8 prevalence present an increased risk of being infected.
KW - Blood transmission
KW - HHV-8
KW - Italy
KW - Kaposi's sarcoma
KW - Thalassemics
KW - Transfusion
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U2 - 10.1016/j.jcv.2003.09.015
DO - 10.1016/j.jcv.2003.09.015
M3 - Article
C2 - 15072763
AN - SCOPUS:11144357397
VL - 30
SP - 106
EP - 109
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
SN - 1386-6532
IS - 1
ER -