High rate of recurrence in renal transplant recipients after a first episode of venous thromboembolism

Daniela Poli, Maria Zanazzi, Emilia Antonucci, Rossella Marcucci, Alberto Rosati, Elisabetta Bertoni, Maurizio Salvadori, Agatina Alessandrello Liotta, Rasanna Abbate, Domenico Prisco, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review

Abstract

Background. No data are available about the optimal duration of oral anticoagulant therapy (OAT) after an episode of venous thromboembolism (VTE) occurring in renal transplant (RT) recipients. Our study was undertaken to evaluate the risk of VTE recurrence in patients developing a first episode of VTE after RT. Methods. Among 484 RT patients, 34 (7%) developed a first VTE: 28/34 VTE patients (Group 1) were prospectively studied, after stopping OAT. Group 1 was compared with a group of 84 patients without history of renal disease who had suffered from a first episode of VTE matched for age, sex and type of thrombotic event (Group 2) and with a matched group of 84 RT recipients with no history of VTE (Group 3). After OAT withdrawal, blood samples were obtained for thrombophilia and clotting activation markers (prothrombin fragment 1+2 (F1+2) and D-dimer plasma levels). Results. During follow-up, 14/28 patients of Group 1 and 8/84 patients of Group 2 experienced VTE recurrence (P

Original languageEnglish
Pages (from-to)789-793
Number of pages5
JournalTransplantation
Volume80
Issue number6
DOIs
Publication statusPublished - Sep 27 2005

Keywords

  • Oral anticoagulant therapy
  • Renal transplant recipients
  • Venous thromboembolism
  • Venous thromboembolism recurrence

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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