High rate of subcutaneous implantable cardioverter-defibrillator sensing screening failure in patients with Brugada syndrome: A comparison with other inherited primary arrhythmia syndromes

Giulio Conte, Mihoko Kawabata, Carlo De Asmundis, Erika Taravelli, Francesco Petracca, Diego Ruggiero, Maria Luce Caputo, François Regoli, Gian Battista Chierchia, Alessandra Chiodini, Alessandro Del Bufalo, Tiziano Moccetti, Masahiko Goya, Kenzo Hirao, Alessandro Vicentini, Gaetano M. De Ferrari, Pedro Brugada, Angelo Auricchio

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Aims Subcutaneous implantable cardioverter-defibrillator (S-ICD) can avoid important complications associated with transvenous leads in patients with inherited primary arrhythmia syndromes, who do not need pacing therapy. Few data are available on the percentage of patients with inherited arrhythmia syndromes eligible for S-ICD implantation. Aim of this study was to analyse the eligibility for S-ICD in a series of patients with Brugada syndrome (BrS), and to compare it with patients with other channelopathies. Methods and results Patients presenting with BrS, long-QT syndrome (LQTS), early repolarization syndrome (ERS), and idiopathic ventricular fibrillation (IVF) were considered eligible for this study. ECG screening was performed by analysis of QRS complex and T wave morphology recorded in standing and supine position. Eligibility was defined when >1 sense vector was acceptable in both supine and standing position. A total of 100 patients (72 males; mean age: 46 ± 17 years) underwent S-ICD sensing screening. Sixty-one patients presented with BrS, 21 with LQTS, 14 with IVF, and 4 with ERS. Thirty-four patients with BrS (56%) presented with spontaneous type 1 ECG. In the other 27 patients (44%), type 1 ECG was unmasked by ajmaline. Overall, rate of screening failure was 13%. Patients with BrS had a higher rate of inappropriate morphology analysis as compared with other channelopathies (18% vs. 5%, P = 0.07) and had a lower number of suitable sensing vectors (49.6% vs. 84.7% vs. P < 0.001). Ajmaline challenge unmasked sensing failure in 14.8% of drug-induced BrS patients previously considered eligible. In all patients, the reason for sensing inappropriateness was due to the presence of high T wave voltages. Conclusion S-ICD screening failure occurs in up to 13% of patients with inherited primary arrhythmia syndromes. Patients with BrS present a higher rate of screening failure as compared with other cardiac channelopathies.

Original languageEnglish
Pages (from-to)1188-1193
Number of pages6
JournalEuropace
Volume20
Issue number7
DOIs
Publication statusPublished - Jul 1 2018
Externally publishedYes

Fingerprint

Brugada Syndrome
Implantable Defibrillators
Cardiac Arrhythmias
Channelopathies
Ajmaline
Long QT Syndrome
Electrocardiography
Supine Position
Posture

Keywords

  • Brugada syndrome
  • Electrocardiogram
  • Eligibility
  • Primary inherited arrhythmia syndromes
  • Subcutaneous implantable cardioverterdefibrillator

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

High rate of subcutaneous implantable cardioverter-defibrillator sensing screening failure in patients with Brugada syndrome : A comparison with other inherited primary arrhythmia syndromes. / Conte, Giulio; Kawabata, Mihoko; De Asmundis, Carlo; Taravelli, Erika; Petracca, Francesco; Ruggiero, Diego; Caputo, Maria Luce; Regoli, François; Chierchia, Gian Battista; Chiodini, Alessandra; Del Bufalo, Alessandro; Moccetti, Tiziano; Goya, Masahiko; Hirao, Kenzo; Vicentini, Alessandro; De Ferrari, Gaetano M.; Brugada, Pedro; Auricchio, Angelo.

In: Europace, Vol. 20, No. 7, 01.07.2018, p. 1188-1193.

Research output: Contribution to journalArticle

Conte, G, Kawabata, M, De Asmundis, C, Taravelli, E, Petracca, F, Ruggiero, D, Caputo, ML, Regoli, F, Chierchia, GB, Chiodini, A, Del Bufalo, A, Moccetti, T, Goya, M, Hirao, K, Vicentini, A, De Ferrari, GM, Brugada, P & Auricchio, A 2018, 'High rate of subcutaneous implantable cardioverter-defibrillator sensing screening failure in patients with Brugada syndrome: A comparison with other inherited primary arrhythmia syndromes', Europace, vol. 20, no. 7, pp. 1188-1193. https://doi.org/10.1093/europace/eux009
Conte, Giulio ; Kawabata, Mihoko ; De Asmundis, Carlo ; Taravelli, Erika ; Petracca, Francesco ; Ruggiero, Diego ; Caputo, Maria Luce ; Regoli, François ; Chierchia, Gian Battista ; Chiodini, Alessandra ; Del Bufalo, Alessandro ; Moccetti, Tiziano ; Goya, Masahiko ; Hirao, Kenzo ; Vicentini, Alessandro ; De Ferrari, Gaetano M. ; Brugada, Pedro ; Auricchio, Angelo. / High rate of subcutaneous implantable cardioverter-defibrillator sensing screening failure in patients with Brugada syndrome : A comparison with other inherited primary arrhythmia syndromes. In: Europace. 2018 ; Vol. 20, No. 7. pp. 1188-1193.
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abstract = "Aims Subcutaneous implantable cardioverter-defibrillator (S-ICD) can avoid important complications associated with transvenous leads in patients with inherited primary arrhythmia syndromes, who do not need pacing therapy. Few data are available on the percentage of patients with inherited arrhythmia syndromes eligible for S-ICD implantation. Aim of this study was to analyse the eligibility for S-ICD in a series of patients with Brugada syndrome (BrS), and to compare it with patients with other channelopathies. Methods and results Patients presenting with BrS, long-QT syndrome (LQTS), early repolarization syndrome (ERS), and idiopathic ventricular fibrillation (IVF) were considered eligible for this study. ECG screening was performed by analysis of QRS complex and T wave morphology recorded in standing and supine position. Eligibility was defined when >1 sense vector was acceptable in both supine and standing position. A total of 100 patients (72 males; mean age: 46 ± 17 years) underwent S-ICD sensing screening. Sixty-one patients presented with BrS, 21 with LQTS, 14 with IVF, and 4 with ERS. Thirty-four patients with BrS (56{\%}) presented with spontaneous type 1 ECG. In the other 27 patients (44{\%}), type 1 ECG was unmasked by ajmaline. Overall, rate of screening failure was 13{\%}. Patients with BrS had a higher rate of inappropriate morphology analysis as compared with other channelopathies (18{\%} vs. 5{\%}, P = 0.07) and had a lower number of suitable sensing vectors (49.6{\%} vs. 84.7{\%} vs. P < 0.001). Ajmaline challenge unmasked sensing failure in 14.8{\%} of drug-induced BrS patients previously considered eligible. In all patients, the reason for sensing inappropriateness was due to the presence of high T wave voltages. Conclusion S-ICD screening failure occurs in up to 13{\%} of patients with inherited primary arrhythmia syndromes. Patients with BrS present a higher rate of screening failure as compared with other cardiac channelopathies.",
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author = "Giulio Conte and Mihoko Kawabata and {De Asmundis}, Carlo and Erika Taravelli and Francesco Petracca and Diego Ruggiero and Caputo, {Maria Luce} and Fran{\cc}ois Regoli and Chierchia, {Gian Battista} and Alessandra Chiodini and {Del Bufalo}, Alessandro and Tiziano Moccetti and Masahiko Goya and Kenzo Hirao and Alessandro Vicentini and {De Ferrari}, {Gaetano M.} and Pedro Brugada and Angelo Auricchio",
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T1 - High rate of subcutaneous implantable cardioverter-defibrillator sensing screening failure in patients with Brugada syndrome

T2 - A comparison with other inherited primary arrhythmia syndromes

AU - Conte, Giulio

AU - Kawabata, Mihoko

AU - De Asmundis, Carlo

AU - Taravelli, Erika

AU - Petracca, Francesco

AU - Ruggiero, Diego

AU - Caputo, Maria Luce

AU - Regoli, François

AU - Chierchia, Gian Battista

AU - Chiodini, Alessandra

AU - Del Bufalo, Alessandro

AU - Moccetti, Tiziano

AU - Goya, Masahiko

AU - Hirao, Kenzo

AU - Vicentini, Alessandro

AU - De Ferrari, Gaetano M.

AU - Brugada, Pedro

AU - Auricchio, Angelo

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Aims Subcutaneous implantable cardioverter-defibrillator (S-ICD) can avoid important complications associated with transvenous leads in patients with inherited primary arrhythmia syndromes, who do not need pacing therapy. Few data are available on the percentage of patients with inherited arrhythmia syndromes eligible for S-ICD implantation. Aim of this study was to analyse the eligibility for S-ICD in a series of patients with Brugada syndrome (BrS), and to compare it with patients with other channelopathies. Methods and results Patients presenting with BrS, long-QT syndrome (LQTS), early repolarization syndrome (ERS), and idiopathic ventricular fibrillation (IVF) were considered eligible for this study. ECG screening was performed by analysis of QRS complex and T wave morphology recorded in standing and supine position. Eligibility was defined when >1 sense vector was acceptable in both supine and standing position. A total of 100 patients (72 males; mean age: 46 ± 17 years) underwent S-ICD sensing screening. Sixty-one patients presented with BrS, 21 with LQTS, 14 with IVF, and 4 with ERS. Thirty-four patients with BrS (56%) presented with spontaneous type 1 ECG. In the other 27 patients (44%), type 1 ECG was unmasked by ajmaline. Overall, rate of screening failure was 13%. Patients with BrS had a higher rate of inappropriate morphology analysis as compared with other channelopathies (18% vs. 5%, P = 0.07) and had a lower number of suitable sensing vectors (49.6% vs. 84.7% vs. P < 0.001). Ajmaline challenge unmasked sensing failure in 14.8% of drug-induced BrS patients previously considered eligible. In all patients, the reason for sensing inappropriateness was due to the presence of high T wave voltages. Conclusion S-ICD screening failure occurs in up to 13% of patients with inherited primary arrhythmia syndromes. Patients with BrS present a higher rate of screening failure as compared with other cardiac channelopathies.

AB - Aims Subcutaneous implantable cardioverter-defibrillator (S-ICD) can avoid important complications associated with transvenous leads in patients with inherited primary arrhythmia syndromes, who do not need pacing therapy. Few data are available on the percentage of patients with inherited arrhythmia syndromes eligible for S-ICD implantation. Aim of this study was to analyse the eligibility for S-ICD in a series of patients with Brugada syndrome (BrS), and to compare it with patients with other channelopathies. Methods and results Patients presenting with BrS, long-QT syndrome (LQTS), early repolarization syndrome (ERS), and idiopathic ventricular fibrillation (IVF) were considered eligible for this study. ECG screening was performed by analysis of QRS complex and T wave morphology recorded in standing and supine position. Eligibility was defined when >1 sense vector was acceptable in both supine and standing position. A total of 100 patients (72 males; mean age: 46 ± 17 years) underwent S-ICD sensing screening. Sixty-one patients presented with BrS, 21 with LQTS, 14 with IVF, and 4 with ERS. Thirty-four patients with BrS (56%) presented with spontaneous type 1 ECG. In the other 27 patients (44%), type 1 ECG was unmasked by ajmaline. Overall, rate of screening failure was 13%. Patients with BrS had a higher rate of inappropriate morphology analysis as compared with other channelopathies (18% vs. 5%, P = 0.07) and had a lower number of suitable sensing vectors (49.6% vs. 84.7% vs. P < 0.001). Ajmaline challenge unmasked sensing failure in 14.8% of drug-induced BrS patients previously considered eligible. In all patients, the reason for sensing inappropriateness was due to the presence of high T wave voltages. Conclusion S-ICD screening failure occurs in up to 13% of patients with inherited primary arrhythmia syndromes. Patients with BrS present a higher rate of screening failure as compared with other cardiac channelopathies.

KW - Brugada syndrome

KW - Electrocardiogram

KW - Eligibility

KW - Primary inherited arrhythmia syndromes

KW - Subcutaneous implantable cardioverterdefibrillator

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