High rates of thioredoxin secretion correlate with growth arrest in hepatoma cells

A. Rubartelli, N. Bonifaci, R. Sitia

Research output: Contribution to journalArticle

Abstract

Thioredoxin (TRX), a disulfide-reducing intracellular dithiol enzyme, is synthesized by both normal liver cells and the hepatocarcinoma cell line HepG2. Only the former, however, secrete abundant TRX extracellularly. When cultured in mild reducing conditions, HepG2 cells but not normal hepatocytes increase the rate or TRX secretion and undergo growth inhibition accompanied by morphological changes. Also, recombinant TRX inhibits proliferation of HepG2 cells. In contrast, exogenous thiols and TRX stimulate proliferation of a B-cell lymphoma line, indicating that different cell types respond differently to variations in the extracellular redox potential.

Original languageEnglish
Pages (from-to)675-680
Number of pages6
JournalCancer Research
Volume55
Issue number3
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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