Il coinvolgimento bronchiale nella sarcoidosi: Studio con tomografia computerizzata con alta risoluzione

Translated title of the contribution: High resolution computed tomography of bronchial involvement in sarcoidosis

Milva Battaglia, Maurizio Zompatori, Antonella Drago, Maria Rita Rimondi, Romeo Canini, Mauro Cavina, Greta Gardelli, Marco Bicocchi

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the HRCT findings of bronchial abnormalities in thoracic sarcoidosis, the posttreatment reversibility of such patterns and their specificity for sarcoidosis. Sixty-one sarcoidosis patients were submitted to chest radiography and HRCT at onset. The diagnosis had transbronchial biopsy confirmation in all patients. HRCT was repeated in 21 patients after a cycle of steroid therapy. Sarcoidosis patients were randomized with 29 patients with diffuse infiltrative lung diseases of different nature. The HRCT findings of bronchial abnormalities follow: extrinsic bronchial compression or displacement by lymphadenopathies (regular/irregular), bronchial wall thickening (regular/irregular), bronchial lumen abnormalities, traction bronchiectasis and bronchiolectasis. Bronchial abnormalities were found in the first HRCT study in 44/61 sarcoidosis patients (72.1%), in 18 patients with extrinsic bronchial compression or displacement by lymphadenopathies (40.9%), in 2 with bronchiectasis or bronchiolectasis (4.5%) and in 24 with one or more other abnormalities (54.5%). Bronchial signs were found in 16/21 patients examined with HRCT after steroid therapy (76.1%). Bronchial abnormalities remained unchanged in 11 patients (68.7%), they improved or disappeared in 5 patients (31%) and appeared ex novo in 2 patients. HRCT patterns of bronchial abnormalities were found in 17/29 patients with other diseases (58.6%), with high rates of bronchial wall thickening and bronchiectasis or bronchiolectasis. The most common HRCT bronchial finding in sarcoidosis was extrinsic bronchial compression of displacement by lymphadenopathies. This was the only sign which could actually differentiate sarcoidosis from other patients (p <0.01). Other signs (bronchial lumen abnormalities and bronchial wall thickening) were frequently found in both sarcoidosis and non-sarcoidosis patients and did not permit to distinguish the former from the latter. In our experience, HRCT findings of bronchial abnormalities were frequently observed in sarcoidosis patients, but they are not specific enough to diagnose sarcoidosis and their usefulness is limited in predicting posttreatment reversibility (activity evaluation) of this condition.

Translated title of the contributionHigh resolution computed tomography of bronchial involvement in sarcoidosis
Original languageItalian
Pages (from-to)199-205
Number of pages7
JournalRadiologia Medica
Volume92
Issue number3
Publication statusPublished - Sep 1996

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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