High resolution, high sensitivity detectors for molecular imaging of small animals and tumor detection

M. L. Magliozzi, E. Cisbani, S. Colilli, F. Cusanno, R. Fratoni, F. Garibaldi, F. Giuliani, M. Gricia, S. Lo Meo, M. Lucentini, F. Santavenere, P. Veneroni, O. Schillaci, G. Simonetti, S. Majewsky, M. N. Cinti, G. De Vincentis, R. Pani, R. Pellegrini, F. Scopinaro

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Imaging techniques with radionuclides provide very sensitive measures of a wide range of specific processes underying disease in the body. Detection of very small tumors with high specificity is therefore possible but the tecnique requires both high spatial resolution and high sensitivity. We present the first simulations, performed by means of GEANT4 code, of breast tumors, imaged by different configurations of a compact discrete gamma camera, in order to optimize the performances of dedicated detectors for these tasks. Simulated planar images from 6 to 10 mm diameter tumors, placed at 5 mm from the collimator, were generated for NaI scintillator pixel sizes of 1.0x1.0 and 1.2x1.2 mm2, hexagonal hole Pb collimators with hole size of 1.5 and 1.9 mm. The generated photons have been sampled by two modelled Hamamatsu H8500 and H9500 PMT. Tumor to background uptake ratio from 1:6 to 1:12 has been considered. The preliminary results in terms of spatial resolution and SNR show a slightly better performance of the high efficiency collimator, larger crystal size and H9500 combination.

Original languageEnglish
Title of host publicationAstroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference
Pages720-724
Number of pages5
Publication statusPublished - 2006
EventInternational Conference on Advanced Technology and Particle Physics, ICATPP 2005 - Como, Italy
Duration: Oct 17 2005Oct 21 2005

Other

OtherInternational Conference on Advanced Technology and Particle Physics, ICATPP 2005
Country/TerritoryItaly
CityComo
Period10/17/0510/21/05

ASJC Scopus subject areas

  • Astronomy and Astrophysics
  • Nuclear and High Energy Physics

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