High-resolution melting assay for genotyping of IFNL4-associated dinucleotide variant rs368234815

E. Galmozzi, F. Facchetti, R. Perbellini, A. Aghemo

Research output: Contribution to journalArticlepeer-review

Abstract

Interferon-λ4-related dinucleotide variant rs368234815 TT/-G is strongly linked with rs12979860 polymorphism, the most important genetic marker connected to treatment-induced hepatitis C virus clearance. Due to additional baseline information that rs368234815 polymorphism could provide for the management of chronic hepatitis C, we developed and validated a high-resolution melting genotyping assay using 193 patients with chronic hepatitis C.

Original languageEnglish
Pages (from-to)O936-O938
JournalClinical Microbiology and Infection
Volume20
Issue number11
DOIs
Publication statusPublished - Nov 1 2014

Keywords

  • IFNL4
  • IL28B
  • Hepatitis c virus
  • High-resolution melting
  • RT-PCR

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

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