Abstract
Purpose: To investigate the changes of the vitreomacular interface during a 1-year follow-up after idiopathic epiretinal membrane (iERM) surgery. Methods: Six patients affected by fovea-attached iERM were recruited in this pilot study. Pars plana vitrectomy associated with epiretinal membrane peeling was performed uneventfully in all cases. In four cases, the inner limiting membrane was removed using Brilliant blue G. En face high-resolution adaptive optics and cross-sectional spectral domain optical coherence tomography retinal imaging were performed before and at 1, 3, 6, and 12 months after surgery. The microstructures of vitreomacular interface in highresolution adaptive optics images were correlated to the cross-sectional spectral domain optical coherence tomography data. Results: Preoperatively, adaptive optics images showed multiple abnormalities of the vitreomacular interface, such as macrofolds, microfolds, and hyperreflective microstructures. We identified two subtypes of iERM according to the distribution of microfolds over the foveal area, which included the radial-type and the grid-type iERM. After surgery, the morphology of the vitreomacular interface changed compared with the preoperative state. The number of both macrofolds and microfolds was reduced in all cases. The hyperreflective structures were still resolvable in all cases, however presenting different shape and morphology than preoperatively. In addition, they showed marked differences between eyes that had internal limiting membrane removal and eyes that did not. Conclusion: Adaptive optics imaging gives new insight into the changes of vitreomacular interface after iERM surgery. Enhanced multimodal imaging of the vitreomacular interface and retinal structures can be valuable to monitor treatment outcome of iERM.
| Original language | English |
|---|---|
| Pages (from-to) | 171-180 |
| Number of pages | 10 |
| Journal | Retina |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2016 |
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Keywords
- Adaptive optics
- Idiopathic epiretinal membrane
- Optical coherence tomography
- Pars plana vitrectomy.
ASJC Scopus subject areas
- Ophthalmology
Cite this
High-resolution multimodal imaging after idiopathic epiretinal membrane surgery. / Lombardo, Marco; Scarinci, Fabio; Giannini, Daniela; Pileri, Marco; Ripandelli, Guido; Stirpe, Mario; Lombardo, Giuseppe; Serrao, Sebastiano.
In: Retina, Vol. 36, No. 1, 2016, p. 171-180.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High-resolution multimodal imaging after idiopathic epiretinal membrane surgery
AU - Lombardo, Marco
AU - Scarinci, Fabio
AU - Giannini, Daniela
AU - Pileri, Marco
AU - Ripandelli, Guido
AU - Stirpe, Mario
AU - Lombardo, Giuseppe
AU - Serrao, Sebastiano
PY - 2016
Y1 - 2016
N2 - Purpose: To investigate the changes of the vitreomacular interface during a 1-year follow-up after idiopathic epiretinal membrane (iERM) surgery. Methods: Six patients affected by fovea-attached iERM were recruited in this pilot study. Pars plana vitrectomy associated with epiretinal membrane peeling was performed uneventfully in all cases. In four cases, the inner limiting membrane was removed using Brilliant blue G. En face high-resolution adaptive optics and cross-sectional spectral domain optical coherence tomography retinal imaging were performed before and at 1, 3, 6, and 12 months after surgery. The microstructures of vitreomacular interface in highresolution adaptive optics images were correlated to the cross-sectional spectral domain optical coherence tomography data. Results: Preoperatively, adaptive optics images showed multiple abnormalities of the vitreomacular interface, such as macrofolds, microfolds, and hyperreflective microstructures. We identified two subtypes of iERM according to the distribution of microfolds over the foveal area, which included the radial-type and the grid-type iERM. After surgery, the morphology of the vitreomacular interface changed compared with the preoperative state. The number of both macrofolds and microfolds was reduced in all cases. The hyperreflective structures were still resolvable in all cases, however presenting different shape and morphology than preoperatively. In addition, they showed marked differences between eyes that had internal limiting membrane removal and eyes that did not. Conclusion: Adaptive optics imaging gives new insight into the changes of vitreomacular interface after iERM surgery. Enhanced multimodal imaging of the vitreomacular interface and retinal structures can be valuable to monitor treatment outcome of iERM.
AB - Purpose: To investigate the changes of the vitreomacular interface during a 1-year follow-up after idiopathic epiretinal membrane (iERM) surgery. Methods: Six patients affected by fovea-attached iERM were recruited in this pilot study. Pars plana vitrectomy associated with epiretinal membrane peeling was performed uneventfully in all cases. In four cases, the inner limiting membrane was removed using Brilliant blue G. En face high-resolution adaptive optics and cross-sectional spectral domain optical coherence tomography retinal imaging were performed before and at 1, 3, 6, and 12 months after surgery. The microstructures of vitreomacular interface in highresolution adaptive optics images were correlated to the cross-sectional spectral domain optical coherence tomography data. Results: Preoperatively, adaptive optics images showed multiple abnormalities of the vitreomacular interface, such as macrofolds, microfolds, and hyperreflective microstructures. We identified two subtypes of iERM according to the distribution of microfolds over the foveal area, which included the radial-type and the grid-type iERM. After surgery, the morphology of the vitreomacular interface changed compared with the preoperative state. The number of both macrofolds and microfolds was reduced in all cases. The hyperreflective structures were still resolvable in all cases, however presenting different shape and morphology than preoperatively. In addition, they showed marked differences between eyes that had internal limiting membrane removal and eyes that did not. Conclusion: Adaptive optics imaging gives new insight into the changes of vitreomacular interface after iERM surgery. Enhanced multimodal imaging of the vitreomacular interface and retinal structures can be valuable to monitor treatment outcome of iERM.
KW - Adaptive optics
KW - Idiopathic epiretinal membrane
KW - Optical coherence tomography
KW - Pars plana vitrectomy.
UR - http://www.scopus.com/inward/record.url?scp=84952916208&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84952916208&partnerID=8YFLogxK
U2 - 10.1097/IAE.0000000000000679
DO - 10.1097/IAE.0000000000000679
M3 - Article
C2 - 26110598
AN - SCOPUS:84952916208
VL - 36
SP - 171
EP - 180
JO - Retina
JF - Retina
SN - 0275-004X
IS - 1
ER -