High-resolution organization of mouse telomeric and pericentromeric DNA

S. Garagna, M. Zuccotti, E. Capanna, C. A. Redi

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the organization of telomeric, major and minor satellite DNA sequences located in the pericentromeric regions of mouse telocentric and Robertsonian metacentric chromosomes by high-resolution fluorescence in situ hybridization. Molecular data have already proved that in telocentrics, from the physical chromosome end, telomeric sequences are followed by minor and then by major satellite DNA. We showed that the three families of repetitive DNA are organized as uninterrupted long-range cluster repeats and that there is no intermingling between telomeric and minor satellite DNA or between the major and the minor tandem repeats or with non-satellite DNA. The pericentromeric region of metacentric chromosomes consists of a small block of minor satellite DNA sandwiched between two blocks of major satellite DNA.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalCytogenetic and Genome Research
Volume96
Issue number1-4
DOIs
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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