High-resolution quantitative imaging of the substantia nigra

Paula Trujillo, Alex K. Smith, Paul E. Summers, Luca M. Mainardi, Sergio Cerutti, Seth A. Smith, Antonella Costa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

There is a growing interest in identifying neuroimaging-based biomarkers for Parkinson's disease (PD), a progressive neurodegenerative disorder in which the major pathologic substrate is the loss of pigmented dopaminergic neurons in the substantia nigra (SN). Recently, an MRI technique dubbed 'neuromelanin-sensitive MRI' (NM-MRI), has been found to provide notable contrast between the SN and surrounding brain tissues with potential applications as biomarker of PD. The contrast in NM-MRI has been associated with magnetization transfer (MT) effects, and thus the goal of this study was to characterize the impact of MT on NM-MRI, and to demonstrate the feasibility of performing quantitative MT (qMT) imaging in human SN. The results of this study demonstrate that high-resolution rapid qMT imaging of the SN can be reliably obtained within reasonable scan times, thereby can be translatable into clinical practice.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages5428-5431
Number of pages4
Volume2015-November
ISBN (Print)9781424492718
DOIs
Publication statusPublished - Nov 4 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: Aug 25 2015Aug 29 2015

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period8/25/158/29/15

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Fingerprint Dive into the research topics of 'High-resolution quantitative imaging of the substantia nigra'. Together they form a unique fingerprint.

  • Cite this

    Trujillo, P., Smith, A. K., Summers, P. E., Mainardi, L. M., Cerutti, S., Smith, S. A., & Costa, A. (2015). High-resolution quantitative imaging of the substantia nigra. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2015-November, pp. 5428-5431). [7319619] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7319619