TY - JOUR
T1 - High-resolution technetium-99m-HMPAO SPECT in patients with probable Alzheimer's disease
T2 - Comparison with fluorine-18-FDG PET
AU - Messa, C.
AU - Perani, D.
AU - Lucignani, G.
AU - Zenorini, A.
AU - Zito, F.
AU - Rizzo, G.
AU - Grassi, F.
AU - Del Sole, A.
AU - Franceschi, M.
AU - Gilardi, M. C.
AU - Fazio, F.
PY - 1994
Y1 - 1994
N2 - SPECT studies of regional cerebral perfusion with a high-resolution system were compared to PET studies of regional cerebral glucose utilization (rCMRglc) in 21 patients with probable Alzheimer's disease (AD). Ten normal subjects were also evaluated with SPECT and 10 with PET. Methods: rCMRglc (for PET) and counts (for SPECT) in the associative cortices were normalized to the average rCMRglc, and counts in the calcarine cortex and basal ganglia were considered as a 'reference area' to obtain a ratio. The ratio differences between patients and controls were tested with ANOVA performed separately for PET and SPECT. Results: The difference between probable AD patients and controls was significant for both PET (p <0.00001) and SPECT (p <0.005); this difference was significant for the frontal, temporal and parietal cortices (p <0.0001) for PET, and for the temporal (p <0.005) and parietal (p <0.001) cortices for SPECT. Temporo-parietal defects were detected in all subjects with PET and in 90% with SPECT. Conclusion: PET and SPECT are able to detect characteristic temporo-parietal abnormalities in probable AD. However, the presence of abnormalities in other associative areas is better evaluated with PET.
AB - SPECT studies of regional cerebral perfusion with a high-resolution system were compared to PET studies of regional cerebral glucose utilization (rCMRglc) in 21 patients with probable Alzheimer's disease (AD). Ten normal subjects were also evaluated with SPECT and 10 with PET. Methods: rCMRglc (for PET) and counts (for SPECT) in the associative cortices were normalized to the average rCMRglc, and counts in the calcarine cortex and basal ganglia were considered as a 'reference area' to obtain a ratio. The ratio differences between patients and controls were tested with ANOVA performed separately for PET and SPECT. Results: The difference between probable AD patients and controls was significant for both PET (p <0.00001) and SPECT (p <0.005); this difference was significant for the frontal, temporal and parietal cortices (p <0.0001) for PET, and for the temporal (p <0.005) and parietal (p <0.001) cortices for SPECT. Temporo-parietal defects were detected in all subjects with PET and in 90% with SPECT. Conclusion: PET and SPECT are able to detect characteristic temporo-parietal abnormalities in probable AD. However, the presence of abnormalities in other associative areas is better evaluated with PET.
KW - Alzheimer's disease
KW - fluorine-18-fluorodeoxyglucose
KW - positron emission tomography
KW - single-photon emission computed tomography
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M3 - Article
C2 - 8294987
AN - SCOPUS:0028013696
VL - 35
SP - 210
EP - 216
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 2
ER -