High-resolution X-ray microtomography for three-dimensional visualization of human stem cell muscle homing

Y. Torrente, M. Gavina, M. Belicchi, F. Fiori, V. Komlev, N. Bresolin, F. Rustichelli

Research output: Contribution to journalArticle

Abstract

In the perspective of clinical translation of stem cell research, it would be advantageous to develop new techniques to detect donor cells after transplantation to track their fate and thus better understand their role in regeneration of damaged and diseased tissues. In this study we use X-ray computed microtomography for three-dimensional visualization of stem cells that were labeled with magnetic nanoparticles and transplanted via intra-arterial infusion. We show that X-ray computed microtomography offers the possibility to detect with high definition and resolution human cells after transplantation, and opens new possibilities for both experimental stem cell research.

Original languageEnglish
Pages (from-to)5759-5764
Number of pages6
JournalFEBS Letters
Volume580
Issue number24
DOIs
Publication statusPublished - Oct 16 2006

Keywords

  • Micro-CT
  • Nanoparticles
  • Stem cells
  • X-ray

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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