Abstract
Objectives: Borderline ovarian tumors (BOTs) represent 10-20% of all epithelial ovarian malignancies. Most of them are comparable to benign cysts but a high-risk group has been recognized. The aim of the study was to analyze different follow-up strategies in high-risk patients. Method: Patients with BOT treated at our institution from 1992 to 2011 were retrospectively reviewed. Clinicopathological features influencing prognosis were analyzed and two different follow-up strategies compared [6-month laparoscopic look (LPS-look): group A vs. ultrasound/CA-125 evaluation: group B]. Results: 70 patients with high-risk BOTs were identified. After a median progression-free survival (PFS) of 43 months, 27% of patients experienced recurrences. Six months after diagnosis, 26 high-risk patients were submitted to LPS-look: at surgery, 6 out of 10 patients presenting evidence of disease were optimally debulked while in the remaining 4, only biopsies were performed. No difference in PFS was registered between group A and B patients, nevertheless a significant increase in PFS was registered among completely versus incompletely debulked patients with evidence of disease at laparoscopy. Conclusion: Clinical follow-up remains the gold standard for BOTs. These very preliminary data seem to suggest that LPS-look may have an impact on the secondary PFS in a subgroup of high-risk patients.
| Original language | English |
|---|---|
| Pages (from-to) | 183-192 |
| Number of pages | 10 |
| Journal | Oncology |
| Volume | 87 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Borderline ovarian tumor
- BOT
- Laparoscopy
- treatment and follow-up
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
High-risk borderline ovarian tumors : Analysis of clinicopathological features and prognostic impact of different follow-up strategies. / Lorusso, Domenica; Ratti, Martina; Ditto, Antonino; Raspagliesi, Francesco.
In: Oncology, Vol. 87, No. 3, 2014, p. 183-192.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High-risk borderline ovarian tumors
T2 - Analysis of clinicopathological features and prognostic impact of different follow-up strategies
AU - Lorusso, Domenica
AU - Ratti, Martina
AU - Ditto, Antonino
AU - Raspagliesi, Francesco
PY - 2014
Y1 - 2014
N2 - Objectives: Borderline ovarian tumors (BOTs) represent 10-20% of all epithelial ovarian malignancies. Most of them are comparable to benign cysts but a high-risk group has been recognized. The aim of the study was to analyze different follow-up strategies in high-risk patients. Method: Patients with BOT treated at our institution from 1992 to 2011 were retrospectively reviewed. Clinicopathological features influencing prognosis were analyzed and two different follow-up strategies compared [6-month laparoscopic look (LPS-look): group A vs. ultrasound/CA-125 evaluation: group B]. Results: 70 patients with high-risk BOTs were identified. After a median progression-free survival (PFS) of 43 months, 27% of patients experienced recurrences. Six months after diagnosis, 26 high-risk patients were submitted to LPS-look: at surgery, 6 out of 10 patients presenting evidence of disease were optimally debulked while in the remaining 4, only biopsies were performed. No difference in PFS was registered between group A and B patients, nevertheless a significant increase in PFS was registered among completely versus incompletely debulked patients with evidence of disease at laparoscopy. Conclusion: Clinical follow-up remains the gold standard for BOTs. These very preliminary data seem to suggest that LPS-look may have an impact on the secondary PFS in a subgroup of high-risk patients.
AB - Objectives: Borderline ovarian tumors (BOTs) represent 10-20% of all epithelial ovarian malignancies. Most of them are comparable to benign cysts but a high-risk group has been recognized. The aim of the study was to analyze different follow-up strategies in high-risk patients. Method: Patients with BOT treated at our institution from 1992 to 2011 were retrospectively reviewed. Clinicopathological features influencing prognosis were analyzed and two different follow-up strategies compared [6-month laparoscopic look (LPS-look): group A vs. ultrasound/CA-125 evaluation: group B]. Results: 70 patients with high-risk BOTs were identified. After a median progression-free survival (PFS) of 43 months, 27% of patients experienced recurrences. Six months after diagnosis, 26 high-risk patients were submitted to LPS-look: at surgery, 6 out of 10 patients presenting evidence of disease were optimally debulked while in the remaining 4, only biopsies were performed. No difference in PFS was registered between group A and B patients, nevertheless a significant increase in PFS was registered among completely versus incompletely debulked patients with evidence of disease at laparoscopy. Conclusion: Clinical follow-up remains the gold standard for BOTs. These very preliminary data seem to suggest that LPS-look may have an impact on the secondary PFS in a subgroup of high-risk patients.
KW - Borderline ovarian tumor
KW - BOT
KW - Laparoscopy
KW - treatment and follow-up
UR - http://www.scopus.com/inward/record.url?scp=84904272357&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904272357&partnerID=8YFLogxK
U2 - 10.1159/000360990
DO - 10.1159/000360990
M3 - Article
C2 - 25033912
AN - SCOPUS:84904272357
VL - 87
SP - 183
EP - 192
JO - Oncology
JF - Oncology
SN - 0030-2414
IS - 3
ER -