High-risk breast lesions at imaging-guided needle biopsy: Usefulness of MRI for treatment decision

Viviana Londero, Chiara Zuiani, Anna Linda, Rossano Girometti, Massimo Bazzocchi, Francesco Sardanelli

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

OBJECTIVE. The purpose of this study is to evaluate the role of MRI for characterization of high-risk breast lesions diagnosed at imaging-guided needle biopsy. MATERIALS AND METHODS. In this retrospective analysis of 220 patients, 227 high-risk lesions (94 papillomas, 64 radial sclerosing lesions, 46 lobular neoplasias, and 23 atypical ductal hyperplasias) found at 11-gauge vacuum-assisted or 14-gauge needle biopsy were studied with dynamic MRI (time resolution, 84 or 88 seconds; gadopentetate dimeglumine or gadobenate dimeglumine, 0.1 mmol/kg). When lesions showed contrast enhancement on subtracted images, they were considered suspicious for malignancy. The reference standard was histopathologic examination after surgical excision in 190 of 227 (84%) lesions and negative follow-up (≥ 24 months) in 37 of 227 (16%) lesions. Predictive values and likelihood ratios were calculated. RESULTS. Of 227 lesions, 155 (68%) were contrast enhancing and 72 (32%) were not. Of 155 contrast-enhancing lesions, 28 (18%) were upgraded to malignancy after surgical excision (nine papillomas, one radial sclerosing lesion, 11 lobular neoplasias, and seven atypical ductal hyperplasias); there were 11 invasive carcinomas and 17 ductal carcinomas in situ, four of the latter being G3. Of 72 non-contrast-enhancing lesions, two (3%) were upgraded to malignancy after surgical excision (one radial sclerosing lesion and one lobular neoplasia), both of which were G1 ductal carcinoma in situ. Cancer probability was significantly higher for contrast-enhancing (18%) than for non-contrast-enhancing (3%) lesions (p = 0.001) and for nonmasslike (43%) than for masslike (14%) lesions (p = 0.005). The positive predictive value was 18% (28/155; 95% CI, 13-24%), the negative predictive value was 97% (70/72; 95% CI, 94-99%), the positive likelihood ratio was 1.448 (95% CI, 1.172-1.788), and the negative likelihood ratio was 0.188 (95% CI, 0.152-0.232). CONCLUSION. The absence of enhancement at dynamic MRI allowed reliable exclusion of invasive cancers among high-risk lesions diagnosed at needle biopsy.

Original languageEnglish
JournalAmerican Journal of Roentgenology
Volume199
Issue number2
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Image-Guided Biopsy
Needle Biopsy
Breast
Carcinoma, Intraductal, Noninfiltrating
Neoplasms
Papilloma
Therapeutics
Gadolinium DTPA
Vacuum
Carcinoma

Keywords

  • Breast cancer
  • Contrast-enhanced MRI
  • Core needle biopsy
  • High-risk breast lesions
  • Vacuum-assisted biopsy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

High-risk breast lesions at imaging-guided needle biopsy : Usefulness of MRI for treatment decision. / Londero, Viviana; Zuiani, Chiara; Linda, Anna; Girometti, Rossano; Bazzocchi, Massimo; Sardanelli, Francesco.

In: American Journal of Roentgenology, Vol. 199, No. 2, 08.2012.

Research output: Contribution to journalArticle

Londero, Viviana ; Zuiani, Chiara ; Linda, Anna ; Girometti, Rossano ; Bazzocchi, Massimo ; Sardanelli, Francesco. / High-risk breast lesions at imaging-guided needle biopsy : Usefulness of MRI for treatment decision. In: American Journal of Roentgenology. 2012 ; Vol. 199, No. 2.
@article{f5c72068b1db4e0d952bb922d9aef87b,
title = "High-risk breast lesions at imaging-guided needle biopsy: Usefulness of MRI for treatment decision",
abstract = "OBJECTIVE. The purpose of this study is to evaluate the role of MRI for characterization of high-risk breast lesions diagnosed at imaging-guided needle biopsy. MATERIALS AND METHODS. In this retrospective analysis of 220 patients, 227 high-risk lesions (94 papillomas, 64 radial sclerosing lesions, 46 lobular neoplasias, and 23 atypical ductal hyperplasias) found at 11-gauge vacuum-assisted or 14-gauge needle biopsy were studied with dynamic MRI (time resolution, 84 or 88 seconds; gadopentetate dimeglumine or gadobenate dimeglumine, 0.1 mmol/kg). When lesions showed contrast enhancement on subtracted images, they were considered suspicious for malignancy. The reference standard was histopathologic examination after surgical excision in 190 of 227 (84{\%}) lesions and negative follow-up (≥ 24 months) in 37 of 227 (16{\%}) lesions. Predictive values and likelihood ratios were calculated. RESULTS. Of 227 lesions, 155 (68{\%}) were contrast enhancing and 72 (32{\%}) were not. Of 155 contrast-enhancing lesions, 28 (18{\%}) were upgraded to malignancy after surgical excision (nine papillomas, one radial sclerosing lesion, 11 lobular neoplasias, and seven atypical ductal hyperplasias); there were 11 invasive carcinomas and 17 ductal carcinomas in situ, four of the latter being G3. Of 72 non-contrast-enhancing lesions, two (3{\%}) were upgraded to malignancy after surgical excision (one radial sclerosing lesion and one lobular neoplasia), both of which were G1 ductal carcinoma in situ. Cancer probability was significantly higher for contrast-enhancing (18{\%}) than for non-contrast-enhancing (3{\%}) lesions (p = 0.001) and for nonmasslike (43{\%}) than for masslike (14{\%}) lesions (p = 0.005). The positive predictive value was 18{\%} (28/155; 95{\%} CI, 13-24{\%}), the negative predictive value was 97{\%} (70/72; 95{\%} CI, 94-99{\%}), the positive likelihood ratio was 1.448 (95{\%} CI, 1.172-1.788), and the negative likelihood ratio was 0.188 (95{\%} CI, 0.152-0.232). CONCLUSION. The absence of enhancement at dynamic MRI allowed reliable exclusion of invasive cancers among high-risk lesions diagnosed at needle biopsy.",
keywords = "Breast cancer, Contrast-enhanced MRI, Core needle biopsy, High-risk breast lesions, Vacuum-assisted biopsy",
author = "Viviana Londero and Chiara Zuiani and Anna Linda and Rossano Girometti and Massimo Bazzocchi and Francesco Sardanelli",
year = "2012",
month = "8",
doi = "10.2214/AJR.11.7869",
language = "English",
volume = "199",
journal = "American Journal of Roentgenology",
issn = "0361-803X",
publisher = "American Roentgen Ray Society",
number = "2",

}

TY - JOUR

T1 - High-risk breast lesions at imaging-guided needle biopsy

T2 - Usefulness of MRI for treatment decision

AU - Londero, Viviana

AU - Zuiani, Chiara

AU - Linda, Anna

AU - Girometti, Rossano

AU - Bazzocchi, Massimo

AU - Sardanelli, Francesco

PY - 2012/8

Y1 - 2012/8

N2 - OBJECTIVE. The purpose of this study is to evaluate the role of MRI for characterization of high-risk breast lesions diagnosed at imaging-guided needle biopsy. MATERIALS AND METHODS. In this retrospective analysis of 220 patients, 227 high-risk lesions (94 papillomas, 64 radial sclerosing lesions, 46 lobular neoplasias, and 23 atypical ductal hyperplasias) found at 11-gauge vacuum-assisted or 14-gauge needle biopsy were studied with dynamic MRI (time resolution, 84 or 88 seconds; gadopentetate dimeglumine or gadobenate dimeglumine, 0.1 mmol/kg). When lesions showed contrast enhancement on subtracted images, they were considered suspicious for malignancy. The reference standard was histopathologic examination after surgical excision in 190 of 227 (84%) lesions and negative follow-up (≥ 24 months) in 37 of 227 (16%) lesions. Predictive values and likelihood ratios were calculated. RESULTS. Of 227 lesions, 155 (68%) were contrast enhancing and 72 (32%) were not. Of 155 contrast-enhancing lesions, 28 (18%) were upgraded to malignancy after surgical excision (nine papillomas, one radial sclerosing lesion, 11 lobular neoplasias, and seven atypical ductal hyperplasias); there were 11 invasive carcinomas and 17 ductal carcinomas in situ, four of the latter being G3. Of 72 non-contrast-enhancing lesions, two (3%) were upgraded to malignancy after surgical excision (one radial sclerosing lesion and one lobular neoplasia), both of which were G1 ductal carcinoma in situ. Cancer probability was significantly higher for contrast-enhancing (18%) than for non-contrast-enhancing (3%) lesions (p = 0.001) and for nonmasslike (43%) than for masslike (14%) lesions (p = 0.005). The positive predictive value was 18% (28/155; 95% CI, 13-24%), the negative predictive value was 97% (70/72; 95% CI, 94-99%), the positive likelihood ratio was 1.448 (95% CI, 1.172-1.788), and the negative likelihood ratio was 0.188 (95% CI, 0.152-0.232). CONCLUSION. The absence of enhancement at dynamic MRI allowed reliable exclusion of invasive cancers among high-risk lesions diagnosed at needle biopsy.

AB - OBJECTIVE. The purpose of this study is to evaluate the role of MRI for characterization of high-risk breast lesions diagnosed at imaging-guided needle biopsy. MATERIALS AND METHODS. In this retrospective analysis of 220 patients, 227 high-risk lesions (94 papillomas, 64 radial sclerosing lesions, 46 lobular neoplasias, and 23 atypical ductal hyperplasias) found at 11-gauge vacuum-assisted or 14-gauge needle biopsy were studied with dynamic MRI (time resolution, 84 or 88 seconds; gadopentetate dimeglumine or gadobenate dimeglumine, 0.1 mmol/kg). When lesions showed contrast enhancement on subtracted images, they were considered suspicious for malignancy. The reference standard was histopathologic examination after surgical excision in 190 of 227 (84%) lesions and negative follow-up (≥ 24 months) in 37 of 227 (16%) lesions. Predictive values and likelihood ratios were calculated. RESULTS. Of 227 lesions, 155 (68%) were contrast enhancing and 72 (32%) were not. Of 155 contrast-enhancing lesions, 28 (18%) were upgraded to malignancy after surgical excision (nine papillomas, one radial sclerosing lesion, 11 lobular neoplasias, and seven atypical ductal hyperplasias); there were 11 invasive carcinomas and 17 ductal carcinomas in situ, four of the latter being G3. Of 72 non-contrast-enhancing lesions, two (3%) were upgraded to malignancy after surgical excision (one radial sclerosing lesion and one lobular neoplasia), both of which were G1 ductal carcinoma in situ. Cancer probability was significantly higher for contrast-enhancing (18%) than for non-contrast-enhancing (3%) lesions (p = 0.001) and for nonmasslike (43%) than for masslike (14%) lesions (p = 0.005). The positive predictive value was 18% (28/155; 95% CI, 13-24%), the negative predictive value was 97% (70/72; 95% CI, 94-99%), the positive likelihood ratio was 1.448 (95% CI, 1.172-1.788), and the negative likelihood ratio was 0.188 (95% CI, 0.152-0.232). CONCLUSION. The absence of enhancement at dynamic MRI allowed reliable exclusion of invasive cancers among high-risk lesions diagnosed at needle biopsy.

KW - Breast cancer

KW - Contrast-enhanced MRI

KW - Core needle biopsy

KW - High-risk breast lesions

KW - Vacuum-assisted biopsy

UR - http://www.scopus.com/inward/record.url?scp=84864778650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864778650&partnerID=8YFLogxK

U2 - 10.2214/AJR.11.7869

DO - 10.2214/AJR.11.7869

M3 - Article

C2 - 22826427

AN - SCOPUS:84864778650

VL - 199

JO - American Journal of Roentgenology

JF - American Journal of Roentgenology

SN - 0361-803X

IS - 2

ER -